Journal article
The yeast spt14 gene is homologous to the human PIG-A gene and is required for GPI anchor synthesis
The EMBO journal, Vol.14(8), pp.1637-1645
04/18/1995
DOI: 10.1002/j.1460-2075.1995.tb07152.x
PMCID: PMC398256
PMID: 7737116
Abstract
The protein encoded by the yeast gene SPT14 shows high sequence similarity to the human protein, PIG-A, whose loss of activity is at the origin of the disease paroxysmal nocturnal hemoglobinuria. The symptoms of this disease are apparently due to a loss of cell surface, glycosylphosphatidylinositol (GPI)-anchored proteins. Like PIG-A mutant cells, spt14 mutant cells are defective in GPI anchoring due to a defect in the synthesis of GlcNAc-PI, the first step of GPI synthesis. The spt14 mutant causes several other abnormalities including transcriptional defects and a downregulation of inositolphosphoceramide synthesis. We suggest that these defects are indirect results of the loss of GPI anchoring.
Details
- Title: Subtitle
- The yeast spt14 gene is homologous to the human PIG-A gene and is required for GPI anchor synthesis
- Creators
- M Schönbächler - Biozentrum, University of Basel, SwitzerlandA Horvath - Biozentrum, University of Basel, SwitzerlandJ Fassler - Biozentrum, University of Basel, SwitzerlandH Riezman - Biozentrum, University of Basel, Switzerland
- Resource Type
- Journal article
- Publication Details
- The EMBO journal, Vol.14(8), pp.1637-1645
- DOI
- 10.1002/j.1460-2075.1995.tb07152.x
- PMID
- 7737116
- PMCID
- PMC398256
- NLM abbreviation
- EMBO J
- ISSN
- 0261-4189
- eISSN
- 1460-2075
- Language
- English
- Date published
- 04/18/1995
- Academic Unit
- Biology
- Record Identifier
- 9984217530602771
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