Journal article
Theophylline Therapy for Near-Fatal Cheyne–Stokes Respiration: A Case Report
Annals of internal medicine, Vol.130(5), pp.427-430
03/02/1999
DOI: 10.7326/0003-4819-130-5-199903020-00014
PMID: 10068417
Abstract
Background: Cheyne-Stokes respiration is characterized by periodic breathing that alternates with hypopnea or apnea.
Objective: To describe the effect of theophylline on near-fatal Cheyne-Stokes respiration.
Design: Case report.
Setting: Tertiary referral center.
Patient: A 48-year-old diabetic woman with a history of three cardiorespiratory arrests, a normal coronary arteriogram, normal left ventricular function, and severe Cheyne-Stokes respiration.
Measurements: Oxygen saturation, intra-arterial blood pressure, central venous pressure, chest wall movement, electrocardiography, electromyography, electroencephalography, electro-oculography, minute ventilation, arterial blood gases, and serum theophylline levels.
Results: After intravenous administration of 1.2 mg of theophylline at 0.6 mg/kg per hour (serum level, 5.6 microg/mL), both Cheyne-Stokes respiration and oxygen desaturation were markedly attenuated. After infusion of 2.4 mg of theophylline (serum level, 11.6 microg/mL), Cheyne-Stokes respiration resolved completely. No change was seen with placebo. Cheyne-Stokes respiration did not recur during outpatient treatment with oral theophylline.
Conclusion: Theophylline may be a rapid and effective therapy for life-threatening Cheyne-Stokes respiration.
Details
- Title: Subtitle
- Theophylline Therapy for Near-Fatal Cheyne–Stokes Respiration: A Case Report
- Creators
- Catherine A PesekRyan CooleyKrzysztof NarkiewiczMark Dyken - University of Iowa, NeurologyNeal L Weintraub
- Resource Type
- Journal article
- Publication Details
- Annals of internal medicine, Vol.130(5), pp.427-430
- DOI
- 10.7326/0003-4819-130-5-199903020-00014
- PMID
- 10068417
- ISSN
- 0003-4819
- eISSN
- 1539-3704
- Language
- English
- Date published
- 03/02/1999
- Academic Unit
- Neurology
- Record Identifier
- 9984020728102771
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