Journal article
Theranostics through Utilizing Cherenkov Radiation of Radioisotope Zr-89 with a Nanocomposite Combination of TiO2 and MnO2
ACS applied materials & interfaces, Vol.15(3), pp.3689-3698
01/25/2023
DOI: 10.1021/acsami.2c09195
PMID: 36573583
Abstract
Cherenkov radiation (CR) derived from the decay of diagnostic and therapeutic radionuclides is currently being studied by the scientific community to determine if these emissions can be harnessed for cancer detection and therapy. While Cherenkov luminescence imaging (CLI) has been studied in the preclinical and clinical settings, Cherenkov radiation-induced cancer therapy (CRICT) is a relatively new area of research that harnesses the emitted photons to kill cancer cells through free radical generation and DNA damage. Nanoparticles seem well suited for developing a theranostic platform that would allow researchers to visualize therapy delivery and also generate the reactive oxygen species necessary to kill cancer cells. Herein, we report the preparation of an 89Zr–TiO2–MnO2 nanocomposite that incorporates transferrin onto the nanoparticle surface to enhance cancer cell growth inhibition. The incorporation of the positron emission tomography (PET) radioisotope 89Zr (half-life: 3.3 days) allowed for the detection of the nanoparticle using PET and for the creation of Cherenkov emissions that interacted with the nanoparticle surface to generate free radicals for therapy delivery. After preparation, these systems were observed to be stable in various media and provided excellent tumor growth control after being intratumorally injected into mice bearing CT-26 tumors. These results demonstrate that a therapeutically efficient CRICT platform can be generated using commercially available and affordable materials.
Details
- Title: Subtitle
- Theranostics through Utilizing Cherenkov Radiation of Radioisotope Zr-89 with a Nanocomposite Combination of TiO2 and MnO2
- Creators
- Pyeong Seok Choi - Korea Atomic Energy Research InstituteJun Young Lee - Korea Atomic Energy Research InstituteJung Ho Chae - Korea Atomic Energy Research InstituteThaddeus Wadas - University of Iowa, RadiologyZhen Cheng - Shanghai Institute of Materia Medica, Chinese Academy of SciencesMin Goo Hur - Korea Atomic Energy Research InstituteJeong Hoon Park - Korea Atomic Energy Research Institute
- Resource Type
- Journal article
- Publication Details
- ACS applied materials & interfaces, Vol.15(3), pp.3689-3698
- Publisher
- American Chemical Society
- DOI
- 10.1021/acsami.2c09195
- PMID
- 36573583
- ISSN
- 1944-8244
- eISSN
- 1944-8252
- Grant note
- DOI: 10.13039/501100003725, name: National Research Foundation of Korea, award: 1711174197, 2017M2A2A6A05016600, 2021M2E7A1079112; DOI: 10.13039/501100003720, name: Korea Atomic Energy Research Institute
- Language
- English
- Date published
- 01/25/2023
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984530394602771
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