Journal article
Therapeutic Strategies for Targeting Mononuclear Phagocytes in Cancer
Journal of pediatric hematology/oncology, Vol.31(1), pp.14-17
01/01/2009
DOI: 10.1097/MPH.0b013e31816e236a
PMID: 19125080
Abstract
The initiation and progression of cancer is dependent oil factors both intrinsic and extrinsic to the malignant cells. Stromal, vascular endothelial. and inflammatory cells are the principal normal populations that support tumors by supplying factors and nutrients. The mononuclear phagocyte lineage. which includes monocytes, macrophages. and dendritic cells is of particular clinical interest because lineage members call enhance tumor angiogenesis and metastasis. or alternately contribute to turner destruction. Thus therapies that regulate these cells represent an innovative approach for improving patient survival in childhood cancer.
Details
- Title: Subtitle
- Therapeutic Strategies for Targeting Mononuclear Phagocytes in Cancer
- Creators
- David S. Dickens - Helen DeVos Children's HospitalPaul T. Jubinsky - Albert Einstein Coll Med, Bronx, NY 10461 USA
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric hematology/oncology, Vol.31(1), pp.14-17
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/MPH.0b013e31816e236a
- PMID
- 19125080
- ISSN
- 1077-4114
- eISSN
- 1536-3678
- Number of pages
- 4
- Language
- English
- Date published
- 01/01/2009
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984354055802771
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