Journal article
Therapeutic approaches for ischemia/reperfusion injury in the liver
Journal of molecular medicine (Berlin, Germany), Vol.77(8), pp.577-592
08/1999
DOI: 10.1007/s001099900029
PMID: 10543390
Abstract
Organ injury caused by transient ischemia followed by reperfusion is associated with a number of clinically and environmentally induced conditions. Ischemia/reperfusion (I/R) conditions arise during surgical interventions such as organ transplantation and coronary bypass surgery, and in diseases such as stroke and cardiac infarct. The destructive effects of I/R arise from the acute generation of reactive oxygen species subsequent to reoxygenation, which inflict direct tissue damage and initiate a cascade of deleterious cellular responses leading to inflammation, cell death, and organ failure. This review summarizes existing and potential approaches for treatment that have been developed from research using model systems of I/R injury. Although I/R injury in the liver is emphasized, other organ systems share similar pathophysiological mechanisms and therapeutic approaches. We also review current knowledge of the molecular events controlling cellular responses to I/R injury, such as activation of AP-1 and NF-κB pathways. Therapeutic strategies aimed at ameliorating I/R damage are focused both on controlling ROS generated at the time of oxygen reperfusion and on intervening in the activated signal transduction cascades. Potential therapies include pharmacological treatment with small molecules, antibodies to cytokines, or free-radical scavenging enzymes, such as superoxide dismutase or catalase. Additionally, the use of gene therapy approaches may significantly contribute to the development of strategies aimed at inhibiting of I/R injury.
Details
- Title: Subtitle
- Therapeutic approaches for ischemia/reperfusion injury in the liver
- Creators
- Chenguang Fan - Molecular Biology Program, College of Medicine, University of Iowa, 51 Newton Road, Iowa City, IA 52242 USARalf M Zwacka - Department of Oncology, University of Edinburgh, Edinburgh UKJohn F Engelhardt - Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, 51 Newton Road, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Journal of molecular medicine (Berlin, Germany), Vol.77(8), pp.577-592
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- DOI
- 10.1007/s001099900029
- PMID
- 10543390
- ISSN
- 0946-2716
- eISSN
- 1432-1440
- Language
- English
- Date published
- 08/1999
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984025590502771
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