Journal article
Therapeutic strategies for the inherited neuropathies
Neuromolecular medicine, Vol.8(1-2), pp.255-278
2006
DOI: 10.1385/NMM:8:1-2:255
PMID: 16775380
Abstract
More than 30 genetic causes have been identified for the inherited neuropathies collectively referred to as Charcot-Marie-Tooth (CMT) disease. Previous therapies for CMT were limited to traditional approaches such as rehabilitation medicine, ambulation aids, and pain management. Identification of the genes causing CMT has led to improved genetic counseling and assistance in family planning. Identification of these genes is beginning to delineate common molecular pathways in multiple forms of CMT that can be exploited in future molecular therapies. Scientifically based clinical trials for CMT are currently being implemented. Techniques of gene therapy are advancing to the point that they may become feasible options for patients with CMT and other neurodegenerative diseases.
Details
- Title: Subtitle
- Therapeutic strategies for the inherited neuropathies
- Creators
- Michael E Shy - Department of Neurology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit MI 48201, USA. m.shy@wayne.edu
- Resource Type
- Journal article
- Publication Details
- Neuromolecular medicine, Vol.8(1-2), pp.255-278
- Publisher
- United States
- DOI
- 10.1385/NMM:8:1-2:255
- PMID
- 16775380
- ISSN
- 1535-1084
- eISSN
- 1559-1174
- Language
- English
- Date published
- 2006
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984020759602771
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