Therapeutic treatment of New Zealand mouse disease by a limited number of anti-idiotypic antibodies conjugated with neocarzinostatin

N Harata; T Sasaki; H Osaki; T Saito; S Shibata; T Muryoi; O Takai; K Yoshinaga

doi:10.1172/JCI114773

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Therapeutic treatment of New Zealand mouse disease by a limited number of anti-idiotypic antibodies conjugated with neocarzinostatin

Journal article

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Therapeutic treatment of New Zealand mouse disease by a limited number of anti-idiotypic antibodies conjugated with neocarzinostatin

N Harata, T Sasaki, H Osaki, T Saito, S Shibata, T Muryoi, O Takai and K Yoshinaga

The Journal of clinical investigation, Vol.86(3), pp.769-776

09/01/1990

DOI: 10.1172/JCI114773

PMCID: PMC296791

PMID: 2144300

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Abstract

-81 and NE-1 idiotypes (Id) of human nephritogenic anti-DNA antibodies are interspecies Id expressed also in NZB/W F1 mice. We tried to manipulate the synthesis of spontaneously occurring anti-DNA antibody using monoclonal anti-Id antibodies (D1E2 and 1F5) conjugated with a cytotoxic agent, neocarzinostatin (NCS). In vivo administration of anti-Id antibodies conjugated with NCS brought about an improvement in the survival rate of female NZB/W F1 mice. It also caused a retardation of development of lupus nephritis and decreased the numbers of anti-DNA-producing cells. The suppression of anti-DNA antibody synthesis was specific and Id-mediated. The results indicate that the use of a limited number of anti-Id antibodies in combination with a cytotoxic agent may be applicable therapeutically to autoimmune diseases.

Details

Title: Subtitle: Therapeutic treatment of New Zealand mouse disease by a limited number of anti-idiotypic antibodies conjugated with neocarzinostatin
Creators: N Harata - Tohoku University
T Sasaki - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
H Osaki - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
T Saito - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
S Shibata - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
T Muryoi - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
O Takai - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
K Yoshinaga - Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
Resource Type: Journal article
Publication Details: The Journal of clinical investigation, Vol.86(3), pp.769-776
DOI: 10.1172/JCI114773
PMID: 2144300
PMCID: PMC296791
ISSN: 0021-9738
eISSN: 1558-8238
Language: English
Date published: 09/01/1990
Academic Unit: Molecular Physiology and Biophysics
Record Identifier: 9984297505502771

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