Thermoregulatory behavior is disrupted in rats with lesions of the anteroventral third ventricular area (AV3V)

Douglas G Whyte; Timothy J Brennan; Alan Kim Johnson

doi:10.1016/j.physbeh.2005.11.019

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Thermoregulatory behavior is disrupted in rats with lesions of the anteroventral third ventricular area (AV3V)

Journal article

Peer reviewed

Thermoregulatory behavior is disrupted in rats with lesions of the anteroventral third ventricular area (AV3V)

Douglas G Whyte, Timothy J Brennan and Alan Kim Johnson

Physiology & behavior, Vol.87(3), pp.493-499

2006

DOI: 10.1016/j.physbeh.2005.11.019

PMID: 16487986

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Abstract

Core body temperature is maintained through a combination of physiological and behavioral effector mechanisms. While the neural pathways involved in autonomic responses to a heat stress are slowly being unraveled, those controlling behavioral responses have remained elusive. We have recently demonstrated that the tissue that surrounds the anteroventral third ventricular region (AV3V) has an important role in the autonomic response to a heat stress. The purpose of the present study was to determine the impact lesions of the AV3V have on naturally occurring thermoregulatory behaviors. Core temperature was elevated at a constant rate (0.03 °C/min) for 90 min using an infrared heat lamp. Animals were videotaped and scored throughout the heating protocol for grooming, escape jumps and postural extension. The frequency of escape jumps and adoption of an extended posture were significantly reduced in AV3V-lesion rats. In contrast, grooming behavior was unaffected by AV3V lesions, although heat-induced salivation was markedly attenuated. These results demonstrate that the AV3V region is pivotal in the regulation of both autonomic and behavioral thermoregulatory effector mechanisms.

Core temperature

Grooming

Heat stress

Heat-escape

Locomotion

Novel environment

Paw withdrawal

Thermoregulation

Details

Title: Subtitle: Thermoregulatory behavior is disrupted in rats with lesions of the anteroventral third ventricular area (AV3V)
Creators: Douglas G Whyte - Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
Timothy J Brennan - Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA
Alan Kim Johnson - Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Physiology & behavior, Vol.87(3), pp.493-499
DOI: 10.1016/j.physbeh.2005.11.019
PMID: 16487986
NLM abbreviation: Physiol Behav
ISSN: 0031-9384
eISSN: 1873-507X
Publisher: Elsevier Inc
Language: English
Date published: 2006
Academic Unit: Psychological and Brain Sciences; Anesthesia; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213409102771

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