Journal article
Theta Oscillations during Active Sleep Synchronize the Developing Rubro-Hippocampal Sensorimotor Network
Current biology, Vol.27(10), pp.1413-1424.e4
05/22/2017
DOI: 10.1016/j.cub.2017.03.077
PMCID: PMC5446093
PMID: 28479324
Abstract
Neuronal oscillations comprise a fundamental mechanism by which distant neural structures establish and express functional connectivity. Long-range functional connectivity between the hippocampus and other forebrain structures is enabled by theta oscillations. Here, we show for the first time that the infant rat red nucleus (RN)—a brainstem sensorimotor structure—exhibits theta (4–7 Hz) oscillations restricted primarily to periods of active (REM) sleep. At postnatal day 8 (P8), theta is expressed as brief bursts immediately following myoclonic twitches; by P12, theta oscillations are expressed continuously across bouts of active sleep. Simultaneous recordings from the hippocampus and RN at P12 show that theta oscillations in both structures are coherent, co-modulated, and mutually interactive during active sleep. Critically, at P12, inactivation of the medial septum eliminates theta in both structures. The developmental emergence of theta-dependent functional coupling between the hippocampus and RN parallels that between the hippocampus and prefrontal cortex. Accordingly, disruptions in the early expression of theta could underlie the cognitive and sensorimotor deficits associated with neurodevelopmental disorders such as autism and schizophrenia.
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•Theta oscillations occur in the infant rat red nucleus (RN) during active sleep•RN theta is first expressed as brief bursts associated with myoclonic twitching•When tonic RN theta emerges at P12, it is tightly coupled with hippocampal theta•Inactivation of the medial septum blocks sleep-related, but not twitch-related, theta
Del Rio-Bermudez et al. show that the infant rat red nucleus—a brainstem sensorimotor structure—exhibits theta oscillations that are tightly coupled with those in the hippocampus. Importantly, this coupling is expressed primarily during active sleep, highlighting a role for state-dependent functional connectivity in early sensorimotor development.
Details
- Title: Subtitle
- Theta Oscillations during Active Sleep Synchronize the Developing Rubro-Hippocampal Sensorimotor Network
- Creators
- Carlos Del Rio-Bermudez - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USAJangjin Kim - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USAGreta Sokoloff - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USAMark S Blumberg - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Current biology, Vol.27(10), pp.1413-1424.e4
- DOI
- 10.1016/j.cub.2017.03.077
- PMID
- 28479324
- PMCID
- PMC5446093
- NLM abbreviation
- Curr Biol
- ISSN
- 0960-9822
- eISSN
- 1879-0445
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000071, name: National Institute of Child Health and Human Development, award: R37-HD081168
- Language
- English
- Date published
- 05/22/2017
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984002347802771
Metrics
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