Journal article
Thiazide and the Thiazide-Like Diuretics: Review of Hydrochlorothiazide, Chlorthalidone, and Indapamide
American journal of hypertension, Vol.35(7), pp.573-586
04/11/2022
DOI: 10.1093/ajh/hpac048
PMID: 35404993
Abstract
Abstract
The term thiazide is universally understood to refer to diuretics that exert their principal action in the distal tubule. The thiazide class is heterogenous and can be further subdivided into compounds containing the benzothiadiazine ring structure—the thiazide-type (e.g., hydrochlorothiazide)—and those lacking the benzothiadiazine ring—the thiazide-like (e.g., chlorthalidone and indapamide) drugs. Thiazide-like agents are longer acting and constitute the diuretics used in most of the cardiovascular outcome trials that established benefits of treatment with diuretics, but pragmatic aspects, such as lack of availability in convenient formulations, limit their use. Regardless of class heterogeneity, thiazides have retained importance in the management of hypertension for over 60 years. They are reliably effective as monotherapy in a majority of hypertensive patients, and augment the efficacy of other classes of antihypertensives when used in combination. Importantly, a thiazide-based treatment regimen lowers cardiovascular events, and their sturdy effect reinforces their place among the recommended first-line agents to treat hypertension in major domestic and international hypertension guidelines. There are few head-to-head comparisons within the class, but potential differences have been explored indirectly as well as in non-blood pressure mechanisms and potential pleiotropic properties. Until proven otherwise, the importance of these differences remains speculative, and clinicians should assume that cardiovascular events will be lowered similarly across agents when equivalent blood pressure reduction occurs. Thiazides remain underutilized, with only about one-third of hypertensive patients receiving them. For many patients, however, a thiazide is an indispensable component of their regimen to achieve adequate blood pressure control.
Graphical Abstract
Details
- Title: Subtitle
- Thiazide and the Thiazide-Like Diuretics: Review of Hydrochlorothiazide, Chlorthalidone, and Indapamide
- Creators
- Michael E Ernst - Roy J. and Lucille A. Carver College of MedicineMichelle A Fravel - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.35(7), pp.573-586
- Publisher
- Oxford University Press
- DOI
- 10.1093/ajh/hpac048
- PMID
- 35404993
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Language
- English
- Date published
- 04/11/2022
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297343302771
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