Thiersindoles A-C: new indole diterpenoids from Penicillium thiersii

Chen Li; James B Gloer; Donald T Wicklow

doi:10.1021/np030192m

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Thiersindoles A-C: new indole diterpenoids from Penicillium thiersii

Journal article

Peer reviewed

Thiersindoles A-C: new indole diterpenoids from Penicillium thiersii

Chen Li, James B Gloer and Donald T Wicklow

Journal of natural products (Washington, D.C.), Vol.66(9), pp.1232-1235

09/2003

DOI: 10.1021/np030192m

PMID: 14510604

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Abstract

Three new 3-substituted indole diterpenoids (thiersindoles A-C; 1-3) have been isolated from organic extracts of a new Penicillium species (P. thiersii). Their structures, including absolute stereochemistry, were determined by analysis of NMR data and application of Mosher's method. Thiersindoles A-C are biogenetically related to the aflavinines, although the [6,6,5] tricyclic diterpenoid skeleton in compounds 1 and 2 is unprecedented in any of the known members of this class.

Animals

Diterpenes - chemistry

Diterpenes - isolation & purification

Diterpenes - pharmacology

Indoles - chemistry

Indoles - isolation & purification

Indoles - pharmacology

Molecular Structure

Nuclear Magnetic Resonance, Biomolecular

Penicillium - chemistry

Stereoisomerism

Details

Title: Subtitle: Thiersindoles A-C: new indole diterpenoids from Penicillium thiersii
Creators: Chen Li - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
James B Gloer
Donald T Wicklow
Resource Type: Journal article
Publication Details: Journal of natural products (Washington, D.C.), Vol.66(9), pp.1232-1235
DOI: 10.1021/np030192m
PMID: 14510604
ISSN: 0163-3864
eISSN: 1520-6025
Language: English
Date published: 09/2003
Academic Unit: Chemistry
Record Identifier: 9984216586402771

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