Journal article
Thin Core Needle Biopsy Crush Preparations in Conjunction With Fine-Needle Aspiration for the Evaluation of Thyroid Nodules : A Complementary Approach
Cancer, Vol.114(6), pp.512-518
2008
DOI: 10.1002/cncr.23982
PMID: 18988285
Abstract
BACKGROUND.
Fine‐needle aspiration (FNA) is widely accepted as the initial test to evaluate thyroid nodules; however, inadequate and suboptimal specimens have been 1 of its limitations. Unsatisfactory rates of 4.1% to 43% have been reported, but suboptimal specimens with adequate epithelial cells and other limiting factors, such as clotting, often are not addressed. The authors' institution has a low unsatisfactory rate, especially for thyroid biopsies performed under ultrasound in the Interventional Radiology (IR) Department. In addition to on‐site evaluation for all cases, they concomitantly use thin, 22/20‐gauge core needle biopsy (CB) crush preparations (CP) for unsatisfactory/suboptimal FNAs. The CB usually is done after 2 FNA passes and, in most cases, is exhausted by making an air‐dried CP, which is evaluated on site for adequacy; any residual tissue is processed for tissue sections. Experience is required to interpret CP on air‐dried smears. In this report, the authors describe a complementary approach to thyroid biopsy that has worked well.
METHODS.
All thyroid FNA and CB/CP that were performed in the IR Department during the year 2005 were reviewed. Follow‐up histology and records of all procedural complications were retrieved.
RESULTS.
Seven hundred thirteen thyroid biopsies qualified, 225 biopsies (31%) had FNA with CB/CP (85% had only CP for evaluation), and 488 biopsies (69%) had only FNA. The final unsatisfactory rate in IR for FNA was 8.7%; this was reduced to 3.4% with the use of CB/CP. The addition of CB also helped to obtain a more definitive diagnosis in suboptimal FNA specimens. Cytologic‐histologic correlation was comparable for FNA only cases and FNA/CB cases. There were no significant procedural complications in CB cases.
CONCLUSIONS.
FNA in conjunction with a thin CB/CP performed during the same procedure is a safe technique that can reduce the rate of unsatisfactory and suboptimal thyroid biopsy.
Details
- Title: Subtitle
- Thin Core Needle Biopsy Crush Preparations in Conjunction With Fine-Needle Aspiration for the Evaluation of Thyroid Nodules : A Complementary Approach
- Creators
- Songlin Zhang - Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United StatesMarina IVANOVIC - Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United StatesAlbert A NEMCEK - Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United StatesDenise V. S DEFRIAS - Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United StatesErin LUCAS - Cytopathology Laboratory, Northwestern Memorial Hospital, Chicago, Illinois, United StatesRitu NAYAR - Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States
- Resource Type
- Journal article
- Publication Details
- Cancer, Vol.114(6), pp.512-518
- Publisher
- Wiley-Blackwell; Hoboken, NJ
- DOI
- 10.1002/cncr.23982
- PMID
- 18988285
- ISSN
- 0008-543X
- eISSN
- 1097-0142
- Language
- English
- Date published
- 2008
- Academic Unit
- Pathology
- Record Identifier
- 9984047613902771
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