Thiosugar nucleotide analogues: synthesis of uridine 5′-(2,3,6-tri- O-acetyl-4- S-acetyl-4-thio-α- d-galactopyranosyl diphosphate)

Jordan Elhalabi; Kevin G Rice

doi:10.1016/S0008-6215(01)00228-2

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Thiosugar nucleotide analogues: synthesis of uridine 5′-(2,3,6-tri- O-acetyl-4- S-acetyl-4-thio-α- d-galactopyranosyl diphosphate)

Journal article

Peer reviewed

Thiosugar nucleotide analogues: synthesis of uridine 5′-(2,3,6-tri- O-acetyl-4- S-acetyl-4-thio-α- d-galactopyranosyl diphosphate)

Jordan Elhalabi and Kevin G Rice

Carbohydrate research, Vol.335(3), pp.159-165

2001

DOI: 10.1016/S0008-6215(01)00228-2

PMID: 11578632

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Abstract

The synthesis of a novel uridine diphosphate galactose (UDP-Gal) analog, (UDP-2,3,6-tri- O-acetyl-4- S-acetyl-4-thio-α- d-galactopyranose) ( 10) is described. Compound 10 contains a sulfur in the place of oxygen at the 4-position of the galactose moiety. Compound 10 represents a protected form of a novel sugar nucleotide analog that can potentially be used during chemoenzymatic synthesis to modify complex oligosaccharides. Graphic

Thio sugars

β-(1→4)-Galactosyltransferase

Sugar nucleotides

Details

Title: Subtitle: Thiosugar nucleotide analogues: synthesis of uridine 5′-(2,3,6-tri- O-acetyl-4- S-acetyl-4-thio-α- d-galactopyranosyl diphosphate)
Creators: Jordan Elhalabi
Kevin G Rice
Resource Type: Journal article
Publication Details: Carbohydrate research, Vol.335(3), pp.159-165
DOI: 10.1016/S0008-6215(01)00228-2
PMID: 11578632
NLM abbreviation: Carbohydr Res
ISSN: 0008-6215
eISSN: 1873-426X
Publisher: Elsevier Ltd
Language: English
Date published: 2001
Academic Unit: Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Medicinal and Natural Products Chemistry
Record Identifier: 9984065502102771

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