Journal article
Thirst and sodium appetite in rats with experimental nephrotic syndrome
Physiology & behavior, Vol.149, pp.317-323
10/01/2015
DOI: 10.1016/j.physbeh.2015.06.032
PMCID: PMC4512181
PMID: 26120029
Abstract
Nephrotic syndrome is a renal disease accompanied by abnormal body fluid balance. The present experiments investigated the role of behavioral mechanisms in contributing to disordered fluid homeostasis in rats with experimentally-induced nephrotic syndrome. The studies examined water and sodium ingestion under ad libitum conditions and in response to dehydration-related challenges in rats made nephrotic by treatment with the antibiotic, adriamycin. Rats with nephrotic syndrome had greater ad libitum water intakes beginning 3weeks after treatment, but daily sodium (0.3M NaCl) intakes were not affected. Nephrotic rats showed attenuated water and sodium intakes after combined treatment with furosemide (10mg/kg) and captopril (2mg/kg), reduced water intakes after 20h of water deprivation, and diminished water intakes, plasma renin activity and aldosterone secretion after subcutaneous isoproterenol (30μg/kg). However, the adriamycin-treated animals had normal water intakes in response to subcutaneous hypertonic saline (4% at 0.75ml/100g) and central injections of angiotensin II (10, 20, and 50ng). The results suggest that water and sodium ingestion in response to hypovolemic/hypotensive stimuli are disturbed in nephrotic rats, and provide evidence that the disordered behaviors reflect disturbances of the peripheral renin–angiotensin–aldosterone system.
•Injections of Adriamycin were used to create a model of nephrosis in rats.•Adriamycin treatment attenuated water drinking to renin-dependent challenges.•Adriamycin treatment reduced sodium intake after acute hypovolemic challenge.•Adriamycin treatment attenuated release of renin and aldosterone to isoproterenol.•Water drinking to osmotic challenge and angiotensin II were not affected.
Details
- Title: Subtitle
- Thirst and sodium appetite in rats with experimental nephrotic syndrome
- Creators
- Jie Xu - Department of Psychological brain sciences, University of Iowa, Iowa City, IA 52242-1407, United StatesAlan Kim Johnson - Department of Psychological brain sciences, University of Iowa, Iowa City, IA 52242-1407, United StatesRobert L Thunhorst - Department of Psychological brain sciences, University of Iowa, Iowa City, IA 52242-1407, United States
- Resource Type
- Journal article
- Publication Details
- Physiology & behavior, Vol.149, pp.317-323
- DOI
- 10.1016/j.physbeh.2015.06.032
- PMID
- 26120029
- PMCID
- PMC4512181
- NLM abbreviation
- Physiol Behav
- ISSN
- 0031-9384
- eISSN
- 1873-507X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 10/01/2015
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
- Record Identifier
- 9984213417602771
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