Journal article
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Nature genetics, Vol.42(12), pp.1077-1085
12/2010
DOI: 10.1038/ng.714
PMCID: PMC3140055
PMID: 21102462
Abstract
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10−60) and 9q31.2 (P = 2.2 × 10−33), we identified 30 new menarche loci (all P < 5 × 10−8) and found suggestive evidence for a further 10 loci (P < 1.9 × 10−6). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
Details
- Title: Subtitle
- Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
- Creators
- Cathy E Elks - Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UKJohn R.B Perry - Genetics of Complex Traits, Peninsula Medical School, University of Exeter, UKPatrick Sulem - deCODE Genetics, Reykjavik, IcelandDaniel I Chasman - Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Avenue East, Boston MA 02215, USANora Franceschini - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USAChunyan He - Department of Public Health, Indiana University School of Medicine, Indiana, USAKathryn L Lunetta - The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USAJenny A Visser - Department of Internal Medicine, Erasmus MC, Rotterdam, the NetherlandsEnda M Byrne - Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, AustraliaDiana L Cousminer - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FinlandDaniel F Gudbjartsson - deCODE Genetics, Reykjavik, IcelandTõnu Esko - Estonian Genome Center, University of Tartu, Tartu, EstoniaBjarke Feenstra - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkJouke-Jan Hottenga - Department of Biological Psychology, VU University Amsterdam, Amsterdam, The NetherlandsDaniel L Koller - Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana, USAZoltán Kutalik - Department of Medical Genetics, University of Lausanne, Lausanne, SwitzerlandPeng Lin - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAMassimo Mangino - Department of Twin Research and Genetic Epidemiology, King’s College London, London, UKMara Marongiu - Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, ItalyPatrick F McArdle - Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USAAlbert V Smith - Icelandic Heart Association, Kopavogur, IcelandLisette Stolk - Department of Internal Medicine, Erasmus MC, Rotterdam, the NetherlandsSophie W van Wingerden - Genetic-Epidemiology Unit, Department of Epidemiology and Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The NetherlandsJing Hua Zhao - Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UKEva Albrecht - Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, GermanyTanguy Corre - Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, ItalyErik Ingelsson - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenCaroline Hayward - MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine, Western General Hospital; Edinburgh, UKPatrik K.E Magnusson - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenErin N Smith - Scripps Genomic Medicine, The Scripps Translational Science Institute, and The Scripps Research Institute, La Jolla, CA, USAShelia Ulivi - Medical Genetics, Department of Reproductive Sciences and Development, University of Trieste, Trieste, ItalyNicole M Warrington - Centre for Genetic Epidemiology and Biostatistics University of Western Australia, AustraliaLina Zgaga - Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, ScotlandHelen Alavere - Estonian Genome Center, University of Tartu, Tartu, EstoniaNajaf Amin - Genetic-Epidemiology Unit, Department of Epidemiology and Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The NetherlandsThor Aspelund - Icelandic Heart Association, Kopavogur, IcelandStefania Bandinelli - Geriatric Unit, Azienda Sanitaria di Firenze, Florence, ItalyInes Barroso - Wellcome Trust Sanger Institute, Hinxton, Cambridge, UKGerald S Berenson - Tulane University, New Orleans, LA, USASven Bergmann - Department of Medical Genetics, University of Lausanne, Lausanne, SwitzerlandHannah Blackburn - Wellcome Trust Sanger Institute, Hinxton, Cambridge, UKEric Boerwinkle - Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USAJulie E Buring - Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Avenue East, Boston MA 02215, USAFabio Busonero - Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, ItalyHarry Campbell - Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, ScotlandStephen J Chanock - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USAWei Chen - Tulane University, New Orleans, LA, USAMarilyn C Cornelis - Department of Nutrition, Harvard School of Public Health, Boston, MA, USADavid Couper - Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USAAndrea D Coviello - Sections of General Internal Medicine, Preventive Medicine and Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, MA, USAPio d’Adamo - Medical Genetics, Department of Reproductive Sciences and Development, University of Trieste, Trieste, ItalyUlf de Faire - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenEco J.C de Geus - Department of Biological Psychology, VU University Amsterdam, Amsterdam, The NetherlandsPanos Deloukas - Wellcome Trust Sanger Institute, Hinxton, Cambridge, UKAngela Döring - Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, GermanyGeorge Davey Smith - MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, BS8 2BN, UKDouglas F Easton - Centre for Cancer Genetic Epidemiology, Departments of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, UKGudny Eiriksdottir - Icelandic Heart Association, Kopavogur, IcelandValur Emilsson - MPRI, Merck & Co., Inc, 126 Lincoln Ave, Rahway, NJ 07065, USAJohan Eriksson - National Institute for Health and Welfare, FinlandLuigi Ferrucci - Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USAAaron R Folsom - Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USATatiana Foroud - Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana, USAMelissa Garcia - Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USAPaolo Gasparini - Medical Genetics, Department of Reproductive Sciences and Development, University of Trieste, Trieste, ItalyFrank Geller - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkChristian Gieger - Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, GermanyVilmundur Gudnason - Icelandic Heart Association, Kopavogur, IcelandPer Hall - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenSusan E Hankinson - Department of Epidemiology, Harvard School of Public Health, Boston, MA, USALiana Ferreli - Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, ItalyAndrew C Heath - Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USADena G Hernandez - Laboratory of Neurogenetics, National Institute of Ageing, Bethesda, MD, USAAlbert Hofman - Department of Epidemiology, Erasmus MC, Rotterdam, the NetherlandsFrank B Hu - Department of Epidemiology, Harvard School of Public Health, Boston, MA, USAThomas Illig - Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, GermanyMarjo-Riitta Järvelin - Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UKAndrew D Johnson - The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USADavid Karasik - Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USAKay-Tee Khaw - Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, CB2 0QQ, UKDouglas P Kiel - Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USATuomas O Kilpeläinen - Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UKIvana Kolcic - Medical School; University of Zagreb; Zagreb, 10000; CroatiaPeter Kraft - Department of Epidemiology, Harvard School of Public Health, Boston, MA, USALenore J Launer - Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USAJoop S.E Laven - Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, the NetherlandsShengxu Li - Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UKJianjun Liu - Human Genetics, Genome Institute of Singapore, SingaporeDaniel Levy - The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USANicholas G Martin - Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, AustraliaWendy L McArdle - Avon Longitudinal Study of Parents and Children (ALSPAC), Department of Social Medicine, University of Bristol, BS8 2BN, UKMads Melbye - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkVincent Mooser - Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, USAJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, IA, USASarah S Murray - Scripps Genomic Medicine, The Scripps Translational Science Institute, and The Scripps Research Institute, La Jolla, CA, USAMichael A Nalls - Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USAPau Navarro - MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine, Western General Hospital; Edinburgh, UKMari Nelis - Estonian Genome Center, University of Tartu, Tartu, EstoniaAndrew R Ness - Department of Oral and Dental Science, University of Bristol, BS1 2LY, UKKate Northstone - Avon Longitudinal Study of Parents and Children (ALSPAC), Department of Social Medicine, University of Bristol, BS8 2BN, UKBen A Oostra - Genetic-Epidemiology Unit, Department of Epidemiology and Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The NetherlandsMunro Peacock - Department of Medicine, Indiana University School of Medicine, Indiana, USALyle J Palmer - Centre for Genetic Epidemiology and Biostatistics University of Western Australia, AustraliaAarno Palotie - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FinlandGuillaume Paré - Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Avenue East, Boston MA 02215, USAAlex N Parker - Amgen, 1 Kendall Square, Building 100, Cambridge, MA 02139, USANancy L Pedersen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenLeena Peltonen - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FinlandCraig E Pennell - School of Women’s and Infants’ Health, The University of Western Australia, AustraliaPaul Pharoah - Centre for Cancer Genetic Epidemiology, Departments of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, UKOzren Polasek - Medical School; University of Zagreb; Zagreb, 10000; CroatiaAndrew S Plump - Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ 07065, USAAnneli Pouta - National Institute for Health and Welfare, FinlandEleonora Porcu - Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, ItalyThorunn Rafnar - deCODE Genetics, Reykjavik, IcelandJohn P Rice - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USASusan M Ring - Avon Longitudinal Study of Parents and Children (ALSPAC), Department of Social Medicine, University of Bristol, BS8 2BN, UKFernando Rivadeneira - Department of Internal Medicine, Erasmus MC, Rotterdam, the NetherlandsIgor Rudan - Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, ScotlandCinzia Sala - Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, ItalyVeikko Salomaa - National Institute for Health and Welfare, FinlandSerena Sanna - Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, ItalyDavid Schlessinger - Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USANicholas J Schork - Scripps Genomic Medicine, The Scripps Translational Science Institute, and The Scripps Research Institute, La Jolla, CA, USAAngelo Scuteri - Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, ItalyAyellet V Segrè - Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USAAlan R Shuldiner - Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USANicole Soranzo - Department of Twin Research and Genetic Epidemiology, King’s College London, London, UKUlla Sovio - Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UKSathanur R Srinivasan - Tulane University, New Orleans, LA, USADavid P Strachan - Division of Community Health Sciences, St. George’s, University of London, London, UKMar-Liis Tammesoo - Estonian Genome Center, University of Tartu, Tartu, EstoniaEmmi Tikkanen - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FinlandDaniela Toniolo - Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, ItalyKim Tsui - Amgen, 1 Kendall Square, Building 100, Cambridge, MA 02139, USALaufey Tryggvadottir - Icelandic Cancer Registry, Reykjavik, IcelandJonathon Tyrer - Centre for Cancer Genetic Epidemiology, Departments of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, UKManuela Uda - Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, ItalyRob M van Dam - Department of Nutrition, Harvard School of Public Health, Boston, MA, USAPeter Vollenweider - Department of Internal Medicine, BH-10 Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, SwitzerlandJoyve B.J van Meurs - Department of Internal Medicine, Erasmus MC, Rotterdam, the NetherlandsGerard Waeber - Department of Internal Medicine, BH-10 Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, SwitzerlandNicholas J Wareham - Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UKDawn M Waterworth - Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, USAMichael N Weedon - Genetics of Complex Traits, Peninsula Medical School, University of Exeter, UKH. Erich Wichmann - Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, GermanyGonneke Willemsen - Department of Biological Psychology, VU University Amsterdam, Amsterdam, The NetherlandsJames F Wilson - Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, ScotlandAlan F Wright - MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine, Western General Hospital; Edinburgh, UKLauren Young - Amgen, 1 Kendall Square, Building 100, Cambridge, MA 02139, USAGuangju Zhai - Department of Twin Research and Genetic Epidemiology, King’s College London, London, UKWei Vivian Zhuang - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USALaura J Bierut - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USADorret I Boomsma - Department of Biological Psychology, VU University Amsterdam, Amsterdam, The NetherlandsHeather A Boyd - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkLaura Crisponi - Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, ItalyEllen W Demerath - Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USACornelia M van Duijn - Genetic-Epidemiology Unit, Department of Epidemiology and Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The NetherlandsMichael J Econs - Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indiana, USATamara B Harris - Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USADavid J Hunter - Department of Epidemiology, Harvard School of Public Health, Boston, MA, USARuth J.F Loos - Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UKAndres Metspalu - Estonian Genome Center, University of Tartu, Tartu, EstoniaGrant W Montgomery - Molecular Epidemiology, Queensland Institute of Medical Research, Brisbane, AustraliaPaul M Ridker - Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Avenue East, Boston MA 02215, USATim D Spector - Department of Twin Research and Genetic Epidemiology, King’s College London, London, UKElizabeth A Streeten - Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USAKari Stefansson - deCODE Genetics, Reykjavik, IcelandUnnur Thorsteinsdottir - deCODE Genetics, Reykjavik, IcelandAndré G Uitterlinden - Department of Internal Medicine, Erasmus MC, Rotterdam, the NetherlandsElisabeth Widen - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FinlandJoanne M Murabito - The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USAKen K Ong - Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UKAnna Murray - Genetics of Complex Traits, Peninsula Medical School, University of Exeter, UK
- Resource Type
- Journal article
- Publication Details
- Nature genetics, Vol.42(12), pp.1077-1085
- DOI
- 10.1038/ng.714
- PMID
- 21102462
- PMCID
- PMC3140055
- NLM abbreviation
- Nat Genet
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Grant note
- U01 HG004423-01 || HG / National Human Genome Research Institute : NHGRI R01 DK058845-11 || DK / National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK R01 DA013423-05 || DA / National Institute on Drug Abuse : NIDA P01 CA089392-08 || CA / National Cancer Institute : NCI U01 HG004422-02 || HG / National Human Genome Research Institute : NHGRI R37 CA054281-17 || CA / National Cancer Institute : NCI N01 AG012109 || AG / National Institute on Aging : NIA U01 DE018903-02 || DE / National Institute of Dental and Craniofacial Research : NIDCR R01 AA007535-08 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA R01 CA047988-20 || CA / National Cancer Institute : NCI U01 HG004728-01 || HG / National Human Genome Research Institute : NHGRI U01 HG004415-02 || HG / National Human Genome Research Institute : NHGRI Z01 CP010200-03 || CP / Division of Cancer Epidemiology and Genetics : NCI U01 HG004402-02 || HG / National Human Genome Research Institute : NHGRI R01 HL086694-03 || HL / National Heart, Lung, and Blood Institute : NHLBI U01 DE018993-01 || DE / National Institute of Dental and Craniofacial Research : NIDCR R01 AR041398-15 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS P01 CA089392-09 || CA / National Cancer Institute : NCI N01 HC055015 || HC / Division of Epidemiology & Clinical Applications : NHLBI U01 HG004422-01 || HG / National Human Genome Research Institute : NHGRI N01 HC055019 || HC / Division of Epidemiology & Clinical Applications : NHLBI R01 AA014041-05 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA R01 AR041398-20 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS M01 RR016500-04 || RR / National Center for Research Resources : NCRR N01 AG050002 || AG / National Institute on Aging : NIA R01 AG016592-10 || AG / National Institute on Aging : NIA R01 HL043851-10 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL087679-03 || HL / National Heart, Lung, and Blood Institute : NHLBI P01 CA087969-13 || CA / National Cancer Institute : NCI N02 HL64278 || HL / National Heart, Lung, and Blood Institute : NHLBI N01 HC055022 || HC / Division of Epidemiology & Clinical Applications : NHLBI U01 HG004729-02 || HG / National Human Genome Research Institute : NHGRI R01 DA019963-02 || DA / National Institute on Drug Abuse : NIDA R01 DA019963-01A2 || DA / National Institute on Drug Abuse : NIDA U01 HG004399-02 || HG / National Human Genome Research Institute : NHGRI R01 HL088119-04 || HL / National Heart, Lung, and Blood Institute : NHLBI N01 HC055016 || HC / Division of Epidemiology & Clinical Applications : NHLBI M01 RR000750-31 || RR / National Center for Research Resources : NCRR 263 MD821336 || MD / National Center on Minority Health and Health Disparities : NCMHD R01 DA012854-09 || DA / National Institute on Drug Abuse : NIDA P01 AG018397-08 || AG / National Institute on Aging : NIA R01 AA013320-05 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA UL1 RR025005-05 || RR / National Center for Research Resources : NCRR N01 HC055021 || HC / Division of Epidemiology & Clinical Applications : NHLBI 263 MD9164 13 || MD / National Center on Minority Health and Health Disparities : NCMHD U01 CA098233-08 || CA / National Cancer Institute : NCI R01 CA063464-10 || CA / National Cancer Institute : NCI R01 HL087641-03 || HL / National Heart, Lung, and Blood Institute : NHLBI RC2 HL102419-02 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 AA013326-05 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA N01 HC025195 || HC / Division of Epidemiology & Clinical Applications : NHLBI P01 CA055075-17 || CA / National Cancer Institute : NCI U01 HG004726-02 || HG / National Human Genome Research Institute : NHGRI R01 DA019963-03 || DA / National Institute on Drug Abuse : NIDA N01 AG012100 || AG / National Institute on Aging : NIA U01 DK062418-06 || DK / National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK N01 HC055020 || HC / Division of Epidemiology & Clinical Applications : NHLBI U01 HL072515-06 || HL / National Heart, Lung, and Blood Institute : NHLBI U01 HG004735-02 || HG / National Human Genome Research Institute : NHGRI U01 HG004436-02 || HG / National Human Genome Research Institute : NHGRI R01 MH066206-05 || MH / National Institute of Mental Health : NIMH R21 AG032598-02 || AG / National Institute on Aging : NIA R03 HD061437-02 || HD / National Institute of Child Health & Human Development : NICHD U10 AA008401-23 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA U01 HL084756-03 || HL / National Heart, Lung, and Blood Institute : NHLBI N01 HC055018 || HC / Division of Epidemiology & Clinical Applications : NHLBI R01 AA013321-05 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA R01 CA040356-15S1 || CA / National Cancer Institute : NCI
- Language
- English
- Date published
- 12/2010
- Academic Unit
- Psychiatry; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Surgery; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025374902771
Metrics
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