Journal article
Thiyl free radical production with hematoporphyrin derivative, cysteine and light: a spin-trapping study
FEBS letters, Vol.177(2), pp.295-299
1984
DOI: 10.1016/0014-5793(84)81303-4
PMID: 6094251
Abstract
Hematoporphyrin derivative, used in photodynamic therapy of cancer, was found to generate the cysteinyl free radical as seen by spin-trapping. Oxygen appears to be an absolute requirement for thiyl radical production. Singlet oxygen may be the initiating species since azide inhibits oxygen uptake and radical production. In addition, the hydroxyl radical, or a radical with similar reactivity, is also observed and is proposed as the precursor for thiyl free radical production.
Hematoporphyrin derivative
Cysteine
Thiyl free radical
Singlet oxygen
Hydroxyl radical
Spin-trapping
Details
- Title: Subtitle
- Thiyl free radical production with hematoporphyrin derivative, cysteine and light: a spin-trapping study
- Creators
- Garry R Buettner - Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.177(2), pp.295-299
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0014-5793(84)81303-4
- PMID
- 6094251
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Language
- English
- Date published
- 1984
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047994802771
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