Journal article
Three-Dimensional Pulmonary Perfusion MRI with Radial Ultrashort Echo Time and Spatial-Temporal Constrained Reconstruction
Magnetic resonance in medicine, Vol.73(2), pp.555-564
02/01/2015
DOI: 10.1002/mrm.25158
PMCID: PMC4156934
PMID: 24604452
Abstract
PurposeTo assess the feasibility of spatial-temporal constrained reconstruction for accelerated regional lung perfusion using highly undersampled dynamic contrast-enhanced (DCE) three-dimensional (3D) radial MRI with ultrashort echo time (UTE).
MethodsA combined strategy was used to accelerate DCE MRI for 3D pulmonary perfusion with whole lung coverage. A highly undersampled 3D radial UTE MRI acquisition was combined with an iterative constrained reconstruction exploiting principal component analysis and wavelet soft-thresholding for dimensionality reduction in space and time. The performance of the method was evaluated using a 3D fractal-based DCE digital lung phantom. Simulated perfusion maps and contrast enhancement curves were compared with ground truth using the structural similarity index (SSIM) to determine robust threshold and regularization levels. Feasibility studies were then performed in a canine and a human subject with 3D radial UTE (TE=0.08 ms) acquisition to assess feasibility of mapping regional 3D perfusion.
ResultsThe method was able to accurately recover perfusion maps in the phantom with a nominal isotropic spatial resolution of 1.5 mm (SSIM of 0.949). The canine and human subject studies demonstrated feasibility for providing artifact-free perfusion maps in a simple 3D breath-held acquisition.
ConclusionThe proposed method is promising for fast and flexible 3D pulmonary perfusion imaging. Magn Reson Med 73:555-564, 2015. (c) 2014 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Three-Dimensional Pulmonary Perfusion MRI with Radial Ultrashort Echo Time and Spatial-Temporal Constrained Reconstruction
- Creators
- Grzegorz Bauman - University of Wisconsin–MadisonKevin M. Johnson - University of Wisconsin–MadisonLaura C. Bell - University of Wisconsin–MadisonJulia V. Velikina - University of Wisconsin–MadisonAlexey A. Samsonov - University of Wisconsin–MadisonScott K. Nagle - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.73(2), pp.555-564
- Publisher
- Wiley
- DOI
- 10.1002/mrm.25158
- PMID
- 24604452
- PMCID
- PMC4156934
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 10
- Grant note
- T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 5T32 CA009206-31; 1UL1RR025011; UL1TR000427; 9U54TR000021; R01NS066982; R01NS065034 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1RR025011 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R21EB009441 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) KL2TR000428 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R01NS065034 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Language
- English
- Date published
- 02/01/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984275059202771
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