Journal article
Three-Dimensional Structure of the Complex between a T Cell Receptor β Chain and the Superantigen Staphylococcal Enterotoxin B
Immunity (Cambridge, Mass.), Vol.9(6), pp.807-816
12/1998
DOI: 10.1016/S1074-7613(00)80646-9
PMID: 9881971
Abstract
Superantigens (SAGs) are a class of immunostimulatory proteins of bacterial or viral origin that activate T cells by binding to the Vβ domain of the T cell antigen receptor (TCR). The three-dimensional structure of the complex between a TCR β chain (mouse Vβ8.2) and the SAG staphylococcal enterotoxin B (SEB) at 2.4 Å resolution reveals why SEB recognizes only certain Vβ families, as well as why only certain SAGs bind mouse Vβ8.2. Models of the TCR-SEB-peptide/MHC class II complex indicate that Vα interacts with the MHC β chain in the TCR-SAG-MHC complex. The extent of the interaction is variable and is largely determined by the geometry of Vα/Vβ domain association. This variability can account for the preferential expression of certain Vα regions among T cells reactive with SEB.
Details
- Title: Subtitle
- Three-Dimensional Structure of the Complex between a T Cell Receptor β Chain and the Superantigen Staphylococcal Enterotoxin B
- Creators
- Hongmin Li - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850, USAAndrea Llera - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850, USADaisuke Tsuchiya - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850, USALukas Leder - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850, USAXavier Ysern - Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20857, USAPatrick M Schlievert - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USAKlaus Karjalainen - Basel Institute for Immunology, Grenzacherstrasse 487, Postfach CH-4005 Basel, SwitzerlandRoy A Mariuzza - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850, USA
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.9(6), pp.807-816
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1074-7613(00)80646-9
- PMID
- 9881971
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 12/1998
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001160702771
Metrics
17 Record Views