Journal article
Three-dimensional Isotropic Functional Imaging of Cystic Fibrosis Using Oxygen-enhanced MRI: Comparison with Hyperpolarized He-3 MRI
Radiology, Vol.290(1), pp.229-237
01/01/2019
DOI: 10.1148/radiol.2018181148
PMCID: PMC6312433
PMID: 30351258
Abstract
Purpose: To compare the performance of three-dimensional radial ultrashort echo time (UTE) oxygen-enhanced (OE) MRI with that of hyperpolarized helium 3 (He-3) MRI with respect to quantitative ventilation measurements in patients with cystic fibrosis (CF).
Materials and Methods: In this prospective study conducted from June 2013 to May 2015, 25 participants with CF aged 10-55 years (14 male; age range, 13-55 years; 11 female; age range, 10-37 years) successfully underwent pulmonary function tests, hyperpolarized He-3 MRI, and OE MRI. OE MRI used two sequential 3.5-minute normoxic and hyperoxic steady-state free-breathing UTE acquisitions. Seven participants underwent imaging at two separate examinations 1-2 weeks apart to assess repeatability. Regional ventilation was quantified as ventilation defect percentage (VDP) individually from OE MRI and hyperpolarized He-3 MRI by using the same automated quantification tool. Bland-Altman analysis, intraclass correlation coefficient (ICC), Spearman correlation coefficient, and Wilcoxon signed-rank test were used to evaluate repeatability.
Results: In all 24 participants, the global VDP measurements from either OE MRI (rho = -0.66, P<.001) or hyperpolarized He-3 MRI (r = 20.75, P<.001) were significantly correlated with the percentage predicted forced expiratory volume in 1 second. VDP reported at OE MRI was 5.0% smaller than (P =.014) but highly correlated with (r = 0.78, P<.001) VDP reported at hyperpolarized He-3 MRI. Both OE MRI-based VDP and hyperpolarized He-3 MRI-based VDP demonstrated good repeatability (ICC = 0.91 and 0.95, respectively; P <=.001).
Conclusion: In lungs with cystic fibrosis, ultrashort echo time oxygen-enhanced MRI showed similar performance compared with hyperpolarized He-3 MRI for quantitative measures of ventilation defects and their repeatability. (c) RSNA, 2018
Details
- Title: Subtitle
- Three-dimensional Isotropic Functional Imaging of Cystic Fibrosis Using Oxygen-enhanced MRI: Comparison with Hyperpolarized He-3 MRI
- Creators
- Wei Zha - University of Wisconsin–MadisonScott K. Nagle - University of Wisconsin–MadisonRobert V. Cadman - University of Wisconsin–MadisonMark L. Schiebler - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.290(1), pp.229-237
- DOI
- 10.1148/radiol.2018181148
- PMID
- 30351258
- PMCID
- PMC6312433
- NLM abbreviation
- Radiology
- ISSN
- 0033-8419
- eISSN
- 1527-1315
- Publisher
- Radiological Soc North America
- Number of pages
- 9
- Grant note
- R01 HL126771; U10 HL109168 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) S10 OD016394 / NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1TR000427 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) UL1 TR000427; UL1 TR002373 / NCATS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R01HL126771 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 01/01/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984275052902771
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