Journal article
Three-dimensional MR Fingerprinting for Quantitative Breast Imaging
Radiology, Vol.290(1), pp.33-40
01/2019
DOI: 10.1148/radiol.2018180836
PMCID: PMC6312432
PMID: 30375925
Abstract
Purpose To develop a fast three-dimensional method for simultaneous T1 and T2 quantification for breast imaging by using MR fingerprinting. Materials and Methods In this prospective study, variable flip angles and magnetization preparation modules were applied to acquire MR fingerprinting data for each partition of a three-dimensional data set. A fast postprocessing method was implemented by using singular value decomposition. The proposed technique was first validated in phantoms and then applied to 15 healthy female participants (mean age, 24.2 years ± 5.1 [standard deviation]; range, 18-35 years) and 14 female participants with breast cancer (mean age, 55.4 years ± 8.8; range, 39-66 years) between March 2016 and April 2018. The sensitivity of the method to B
field inhomogeneity was also evaluated by using the Bloch-Siegert method. Results Phantom results showed that accurate and volumetric T1 and T2 quantification was achieved by using the proposed technique. The acquisition time for three-dimensional quantitative maps with a spatial resolution of 1.6 × 1.6 × 3 mm
was approximately 6 minutes. For healthy participants, averaged T1 and T2 relaxation times for fibroglandular tissues at 3.0 T were 1256 msec ± 171 and 46 msec ± 7, respectively. Compared with normal breast tissues, higher T2 relaxation time (68 msec ± 13) was observed in invasive ductal carcinoma (P < .001), whereas no statistical difference was found in T1 relaxation time (1183 msec ± 256; P = .37). Conclusion A method was developed for breast imaging by using the MR fingerprinting technique, which allows simultaneous and volumetric quantification of T1 and T2 relaxation times for breast tissues. © RSNA, 2018 Online supplemental material is available for this article.
Details
- Title: Subtitle
- Three-dimensional MR Fingerprinting for Quantitative Breast Imaging
- Creators
- Yong Chen - University Hospitals of ClevelandAnanya Panda - Case Western Reserve UniversityShivani Pahwa - University Hospitals of ClevelandJesse I Hamilton - University Hospitals of ClevelandSara Dastmalchian - University Hospitals of ClevelandDebra F McGivney - University Hospitals of ClevelandDan Ma - University Hospitals of ClevelandJoshua Batesole - University Hospitals of ClevelandNicole Seiberlich - University Hospitals of ClevelandMark A Griswold - University Hospitals of ClevelandDonna Plecha - University Hospitals of ClevelandVikas Gulani - University Hospitals of Cleveland
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.290(1), pp.33-40
- Publisher
- Radiological Society of North America (RSNA)
- DOI
- 10.1148/radiol.2018180836
- PMID
- 30375925
- PMCID
- PMC6312432
- ISSN
- 0033-8419
- eISSN
- 1527-1315
- Grant note
- R21 EB026764 / NIBIB NIH HHS R01 DK098503 / NIDDK NIH HHS R01 EB016728 / NIBIB NIH HHS UL1 TR000004 / NCATS NIH HHS R01 EB017219 / NIBIB NIH HHS
- Language
- English
- Date published
- 01/2019
- Academic Unit
- Radiology
- Record Identifier
- 9984697621402771
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