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Three dimensional geometry of acutely ischemic myocardium
Journal article   Open access   Peer reviewed

Three dimensional geometry of acutely ischemic myocardium

Melvin L Marcus, Richard E Kerber, James Ehrhardt and François M Abboud
Circulation (New York, N.Y.), Vol.52(2), pp.254-263
08/1975
DOI: 10.1161/01.cir.52.2.254
PMID: 1149207
url
https://doi.org/10.1161/01.cir.52.2.254View
Published (Version of record) Open Access

Abstract

The distribution of coronary flow to small segments of the entire left ventricle (96 per dog; average weight = 0.78 g) was studied in 28 open-chested dogs utilizing 7-10 mu labeled microspheres. Although the flow to large areas of the ventricle was nearly evenly distributed, there was considerable heterogeneity of flow to small adjacent segments of myocardium (average standard deviation of the flow distributions was 17.3 +/- 3.2% of mean lfow). Approximately one-half of the measured heterogeneity of flow could be attributed to various extraneous factors, and one-half appears to be due to inherent heterogeneity of flow in the left ventricular myocardium. In ten of 28 dogs, the mid-circumglex coronary was suddenly occluded, and five minutes thereafter the distribution of left ventricular flow was determined with microspheres labeled with a different isotope. The ischemic regments were separated into three groups: severely ischemic, moderately ischemic, and borderline ischemic. The three dimmensional geometry of the acutely ischemic myocardium was analyzed, and four general conclusions were reached. 1) The percent distribution of severely ischemic segments, moderately ischemic segments, and borderline ischemic segments within an ischemic region varies from animal to animal. 2) Subendocardial segments were more frequently and more severely affected than neighboring mid-wall or epicardial segments. 3) No evidence of an "hyperperfused zone" of myocardium surrounding the ischemic area was found. 4) The flows to segments immediately adjacent to the severely ischemic segments were heterogeneous. Therefore, the concept of a geometrically defined "buffer zone" of moderately ischemic myocardium surrounding and separating severely ischemic from normally perfused myocardium no longer seems realistic.
 Blood Pressure Coronary Circulation Heart - physiopathology Heart Rate Cardiac Output Coronary Disease - physiopathology Male Myocardium - pathology Coronary Vessels Microspheres Coronary Disease - pathology Animals Blood Flow Velocity Dogs Electrocardiography Female Disease Models, Animal

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