Three-dimensional hippocampal MR morphometry with high-dimensional transformation of a neuroanatomic atlas

J W Haller; Ayananshu Banerjee; Gary E Christensen; M Gado; S Joshi; Michael I Miller; Y Sheline; M W Vannier; J G Csernansky

doi:10.1148/radiology.202.2.9015081

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Three-dimensional hippocampal MR morphometry with high-dimensional transformation of a neuroanatomic atlas

Journal article

Peer reviewed

Three-dimensional hippocampal MR morphometry with high-dimensional transformation of a neuroanatomic atlas

J W Haller, Ayananshu Banerjee, Gary E Christensen, M Gado, S Joshi, Michael I Miller, Y Sheline, M W Vannier and J G Csernansky

Radiology, Vol.202(2), pp.504-510

02/1997

DOI: 10.1148/radiology.202.2.9015081

PMID: 9015081

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Abstract

To test automated three-dimensional magnetic resonance (MR) imaging morphometry of the human hippocampus, to determine the potential gain in precision compared with conventional manual morphometry. A canonical three-dimensional MR image atlas was used as a deformable template and automatically matched to three-dimensional MR images of 10 individuals (five healthy and five schizophrenic subjects). A subvolume containing the hippocampus was defined by using 16 landmarks that constrained the automated search for hippocampal boundaries. Transformation of the hippocampus template was automatically performed by using global pattern matching through a sequence of low-then high-dimensional translations, rotations, and scalings. The average test-retest volume difference measured with the automatic method was 3.1%, compared with the manual test-retest difference of 7.1%. Correlation between automated and manually determined volumes demonstrated the validity of the automated technique (intraclass correlation coefficient = .86). The automated method estimates hippocampal volumes with less variability (ie, lower variance) than that of manual out-lining.

Image Processing, Computer-Assisted

Humans

Magnetic Resonance Imaging - methods

Adult

Hippocampus - anatomy & histology

Hippocampus - pathology

Schizophrenia - pathology

Details

Title: Subtitle: Three-dimensional hippocampal MR morphometry with high-dimensional transformation of a neuroanatomic atlas
Creators: J W Haller - Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Ayananshu Banerjee
Gary E Christensen
M Gado
S Joshi
Michael I Miller
Y Sheline
M W Vannier
J G Csernansky
Resource Type: Journal article
Publication Details: Radiology, Vol.202(2), pp.504-510
Publisher: United States
DOI: 10.1148/radiology.202.2.9015081
PMID: 9015081
ISSN: 0033-8419
eISSN: 1527-1315
Grant note: R01 NS35368 / NINDS NIH HHS
Language: English
Date published: 02/1997
Academic Unit: Electrical and Computer Engineering; Radiation Oncology; Radiation Research Laboratory
Record Identifier: 9984047782302771

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