Three-dimensional segmentation of fluid-associated abnormalities in retinal OCT: probability constrained graph-search-graph-cut

Xinjian Chen; Meindert Niemeijer; Li Zhang; Kyungmoo Lee; Michael D Abramoff; Milan Sonka

doi:10.1109/TMI.2012.2191302

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Three-dimensional segmentation of fluid-associated abnormalities in retinal OCT: probability constrained graph-search-graph-cut

Journal article

Peer reviewed

Three-dimensional segmentation of fluid-associated abnormalities in retinal OCT: probability constrained graph-search-graph-cut

Xinjian Chen, Meindert Niemeijer, Li Zhang, Kyungmoo Lee, Michael D Abramoff and Milan Sonka

IEEE transactions on medical imaging, Vol.31(8), pp.1521-1531

08/2012

DOI: 10.1109/TMI.2012.2191302

PMCID: PMC3659794

PMID: 22453610

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Abstract

An automated method is reported for segmenting 3-D fluid-associated abnormalities in the retina, so-called symptomatic exudate-associated derangements (SEAD), from 3-D OCT retinal images of subjects suffering from exudative age-related macular degeneration. In the first stage of a two-stage approach, retinal layers are segmented, candidate SEAD regions identified, and the retinal OCT image is flattened using a candidate-SEAD aware approach. In the second stage, a probability constrained combined graph search-graph cut method refines the candidate SEADs by integrating the candidate volumes into the graph cut cost function as probability constraints. The proposed method was evaluated on 15 spectral domain OCT images from 15 subjects undergoing intravitreal anti-VEGF injection treatment. Leave-one-out evaluation resulted in a true positive volume fraction (TPVF), false positive volume fraction (FPVF) and relative volume difference ratio (RVDR) of 86.5%, 1.7%, and 12.8%, respectively. The new graph cut-graph search method significantly outperformed both the traditional graph cut and traditional graph search approaches (p < 0.01, p < 0.04) and has the potential to improve clinical management of patients with choroidal neovascularization due to exudative age-related macular degeneration.

Algorithms

Reproducibility of Results

Humans

Imaging, Three-Dimensional - methods

Tomography, Optical Coherence - methods

Retina - pathology

Exudates and Transudates

Macular Degeneration - pathology

Details

Title: Subtitle: Three-dimensional segmentation of fluid-associated abnormalities in retinal OCT: probability constrained graph-search-graph-cut
Creators: Xinjian Chen - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242, USA. xinjian-chen@uiowa.edu
Meindert Niemeijer
Li Zhang
Kyungmoo Lee
Michael D Abramoff
Milan Sonka
Resource Type: Journal article
Publication Details: IEEE transactions on medical imaging, Vol.31(8), pp.1521-1531
DOI: 10.1109/TMI.2012.2191302
PMID: 22453610
PMCID: PMC3659794
NLM abbreviation: IEEE Trans Med Imaging
ISSN: 0278-0062
eISSN: 1558-254X
Publisher: Institute of Electrical and Electronics Engineers; United States
Grant note: R01 EB004640 / NIBIB NIH HHS EY017066 / NEI NIH HHS R01 EY017066 / NEI NIH HHS R01 EY019112-02 / NEI NIH HHS R01 EY019112 / NEI NIH HHS R01 EY019112-03 / NEI NIH HHS EB004640 / NIBIB NIH HHS R01 EY019112-01A2 / NEI NIH HHS R01 EY018853 / NEI NIH HHS
Language: English
Date published: 08/2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9983806269202771

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