Journal article
Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice
PloS one, Vol.9(9), pp.e107206-e107206
2014
DOI: 10.1371/journal.pone.0107206
PMCID: PMC4161399
PMID: 25211467
Abstract
High-fructose diets have been implicated in obesity via impairment of leptin signaling in humans and rodents. We investigated whether fructose-induced leptin resistance in mice could be used to study the metabolic consequences of fructose consumption in humans, particularly in children and adolescents. Male C57Bl/6 mice were weaned to a randomly assigned diet: high fructose, high sucrose, high fat, or control (sugar-free, low-fat). Mice were maintained on their diets for at least 14 weeks. While fructose-fed mice regularly consumed more kcal and expended more energy, there was no difference in body weight compared to control by the end of the study. Additionally, after 14 weeks, both fructose-fed and control mice displayed similar leptin sensitivity. Fructose-feeding also did not change circulating glucose, triglycerides, or free fatty acids. Though fructose has been linked to obesity in several animal models, our data fail to support a role for fructose intake through food lasting 3 months in altering of body weight and leptin signaling in mice. The lack of impact of fructose in the food of growing mice on either body weight or leptin sensitivity over this time frame was surprising, and important information for researchers interested in fructose and body weight regulation.
Details
- Title: Subtitle
- Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice
- Creators
- Erik J Tillman - Department of Biology, Williams College, Williamstown, Massachusetts, United States of AmericaDonald A Morgan - Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of AmericaKamal Rahmouni - Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of AmericaSteven J Swoap - Department of Biology, Williams College, Williamstown, Massachusetts, United States of America
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.9(9), pp.e107206-e107206
- DOI
- 10.1371/journal.pone.0107206
- PMID
- 25211467
- PMCID
- PMC4161399
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- R15AG37959-1 / NIA NIH HHS P01 HL084207 / NHLBI NIH HHS HL084207 / NHLBI NIH HHS R15 AG037959 / NIA NIH HHS
- Language
- English
- Date published
- 2014
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040014602771
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