Journal article
Thromboembolic events in cancer patients on active treatment with cisplatin-based chemotherapy: another look
Thrombosis journal, Vol.16(1), pp.2-2
03/01/2018
DOI: 10.1186/s12959-018-0161-9
PMCID: PMC5831696
PMID: 29507532
Abstract
Background: The risk of thromboembolic events is higher among cancer patients, especially in patients undergoing chemotherapy. Cisplatin-based regimens claim to be associated with a very high thromboembolic rate. In this study, we report on our own experience with thrombosis among patients on active cisplatin-based chemotherapy.
Methods: Medical records and hospital databases were searched for all the patients treated with any cisplatin-based regimen for any kind of cancer. Thrombosis was considered cisplatin-related if diagnosed any time after the first dose and up to 4 weeks after the last. The Khorana risk assessment model was performed in all cases.
Results: A total of 1677 patients (65.5% males, median age: 50 years) treated with cisplatin-based regimens were identified. Head and neck (22.9%), lung (22.2%), lymphoma and gastric (11.4% each) were the most common primary tumors. Thromboembolic events were reported in 110 (6.6%); the highest was in patients with gastric cancer (20.9%) and the lowest in patients with head and neck cancers (2.3%) and lymphoma (1.6%). Thrombosis included deep vein thrombosis (DVT) in 69 (62.7%), pulmonary embolism (PE) in 18 (16.9%) and arterial thrombosis in 17 (15.6%). A majority (51.1%) of the patients had stage IV disease and only 16% had stage I or II. In a multivariate analysis, significantly higher rates of thrombosis were associated with gastric as the primary tumor, advanced-stage disease, female sex but not age, and the Khorana risk score or type of cisplatin regimen. While the presence of CVC was significantly associated with the risk of thrombosis (p < 0.0001) in the univariate analysis, and such significance was lost in the multivariate analysis (odds ratio, 1.098; 95% CI, 0.603-1.999, p = 0.7599).
Conclusions: Thromboembolic events in cancer patients on active cisplatin-based chemotherapy were commonly encountered. Gastric cancer, regardless of other clinical variables, was associated with the highest risk.
Details
- Title: Subtitle
- Thromboembolic events in cancer patients on active treatment with cisplatin-based chemotherapy: another look
- Creators
- Hikmat Abdel-Razeq - King Hussein Cancer CenterAsem Mansour - King Hussein Cancer CenterHazem Abdulelah - King Hussein Cancer CenterAnas Al-Shwayat - King Hussein Cancer CenterMohammad Makoseh - King Hussein Canc Ctr, Dept Internal Med, 202 Queen Rania Al Abdulla St,POB 1269, Amman 11941, JordanMohammad Ibrahim - King Hussein Cancer CenterMahmoud Abunasser - King Hussein Cancer CenterDalia Rimawi - King Hussein Cancer CenterAbeer Al-Rabaiah - King Hussein Cancer CenterRozan Alfar - King Hussein Canc Ctr, Dept Internal Med, 202 Queen Rania Al Abdulla St,POB 1269, Amman 11941, JordanAlaa Abufara - King Hussein Cancer CenterAlaa Ibrahim - King Hussein Cancer CenterAnas Bawaliz - King Hussein Cancer CenterYousef Ismael - King Hussein Cancer Center
- Resource Type
- Journal article
- Publication Details
- Thrombosis journal, Vol.16(1), pp.2-2
- Publisher
- Springer Nature
- DOI
- 10.1186/s12959-018-0161-9
- PMID
- 29507532
- PMCID
- PMC5831696
- ISSN
- 1477-9560
- eISSN
- 1477-9560
- Number of pages
- 7
- Language
- English
- Date published
- 03/01/2018
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984313085002771
Metrics
4 Record Views