Journal article
Thrombolytic along with anti-platelet activity of crinumin, a protein constituent of Crinum asiaticum
Blood cells, molecules, & diseases, Vol.47(2), pp.129-132
2011
DOI: 10.1016/j.bcmd.2011.06.003
PMID: 21742519
Abstract
Several anticoagulants, anti-platelet and thrombolytic medications are used for the treatment of thrombotic disorders. Anti-coagulants and anti-platelet agents prevent the formation of blood clots but do not dissolve existing clots, whereas thrombolytic agents are able to dissolve a clot but emboli can form even after successful treatment. Thus, none of them provide a permanent and complete solution. In this regard a single molecule that could both dissolve the clot and prevent the formation of new clots would be useful in the treatment of thrombotic diseases. Crinumin, a stable and active (in many adverse conditions) serine protease, shows plasmin-like fibrinolytic activity and inhibits platelet aggregation and P-selectin exposure, as established by photography, phase contrast microscopy, whole blood optical Lumi-aggregometry and flow cytometry. Crinumin could be an efficient and inexpensive therapeutic agent for the treatment and prevention of thromboembolic diseases.
► First report to explore the thrombolytic activity of crinumin. ► Crinumin has also a potential anti-platelet activity. ► May helpful to develop a multifunctional drug regarding the thrombus related diseases.
Details
- Title: Subtitle
- Thrombolytic along with anti-platelet activity of crinumin, a protein constituent of Crinum asiaticum
- Creators
- Kunwar Awaneesh Singh - Banaras Hindu UniversityManasa K. Nayak - Banaras Hindu UniversityMedicherla V. Jagannadham - Banaras Hindu UniversityDebabrata Dash - Banaras Hindu University
- Resource Type
- Journal article
- Publication Details
- Blood cells, molecules, & diseases, Vol.47(2), pp.129-132
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.bcmd.2011.06.003
- PMID
- 21742519
- ISSN
- 1079-9796
- eISSN
- 1096-0961
- Language
- English
- Date published
- 2011
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359793002771
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