Journal article
Thrombosis in the setting of obesity or inflammatory bowel disease
Hematology, Vol.2016(1), pp.180-187
12/01/2016
DOI: 10.1182/asheducation-2016.1.180
PMCID: PMC6142463
PMID: 27913478
Abstract
Obesity and inflammatory bowel disease (IBD) are systemic inflammatory disorders that predispose to arterial and venous thrombosis through similar prothrombotic mechanisms. Obesity and IBD are chronic risk factors that lead to a persistently elevated risk of thrombosis, although the thrombotic risk with IBD appears to wax and wane with disease severity. Because of the lack of high-quality evidence to guide management decisions, approaches to the prevention and treatment of thrombosis in patients with obesity or IBD are based on extrapolation from general guidelines for antithrombotic therapy. Obesity alters the pharmacokinetics of some anticoagulant drugs, and IBD patients present the added management challenge of having a high risk of gastrointestinal bleeding while taking anticoagulants. An extended duration of anticoagulant therapy is often recommended for obese or IBD patients with unprovoked venous thromboembolism unless there is a high risk of bleeding, although more data and better biomarkers are needed to determine whether anticoagulation can be safely stopped in a subset of IBD patients during remission of active disease. Most patients with obesity or IBD require thromboprophylaxis in conjunction with hospitalization or surgery, with adjustment of anticoagulant dosing in patients with severe obesity.
Details
- Title: Subtitle
- Thrombosis in the setting of obesity or inflammatory bowel disease
- Creators
- Steven R. Lentz - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Hematology, Vol.2016(1), pp.180-187
- Publisher
- Amer Soc Hematology
- DOI
- 10.1182/asheducation-2016.1.180
- PMID
- 27913478
- PMCID
- PMC6142463
- ISSN
- 1520-4391
- eISSN
- 1520-4383
- Number of pages
- 8
- Grant note
- Novo Nordisk
- Language
- English
- Date published
- 12/01/2016
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359936202771
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