Thrombus Inducing Property of Atomically Thin Graphene Oxide Sheets

Sunil K. Singh; Manoj K. Singh; Manasa K. Nayak; Sharda Kumari; Siddhartha Shrivastava; Jose J. A. Gracio; Debabrata Dash

doi:10.1021/nn201092p

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Thrombus Inducing Property of Atomically Thin Graphene Oxide Sheets

Journal article

Peer reviewed

Thrombus Inducing Property of Atomically Thin Graphene Oxide Sheets

Sunil K. Singh, Manoj K. Singh, Manasa K. Nayak, Sharda Kumari, Siddhartha Shrivastava, Jose J. A. Gracio and Debabrata Dash

ACS nano, Vol.5(6), pp.4987-4996

06/01/2011

DOI: 10.1021/nn201092p

PMID: 21574593

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Abstract

Graphene oxide (GO), the new two-dimensional carbon nanomaterial, is extensively Investigated for potential biomedical applications. Thus, it is pertinent to critically evaluate its untoward effects on physiology of tissue systems including blood platelets, the cells responsible for maintenance of hemostasis and thrombus formation. Here we report for the first time that atomically thin GO sheets elicited strong aggregatory response in platelets through activation of Src kinases and release of calcium from intracellular stores. Compounding this, intravenous administration of GO was found to induce extensive pulmonary thromboembolism in mice. Prothrombotic character of GO was dependent on surface charge distribution as reduced GO (RGO) was significantly less effective in aggregating platelets. Our findings raise a concern on putative biomedical applications of GO in the form of diagnostic and therapeutic tools where its prothrombotic property should be carefully investigated.

Chemistry

Chemistry, Multidisciplinary

Chemistry, Physical

Materials Science

Materials Science, Multidisciplinary

Nanoscience & Nanotechnology

Physical Sciences

Science & Technology

Science & Technology - Other Topics

Technology

Details

Title: Subtitle: Thrombus Inducing Property of Atomically Thin Graphene Oxide Sheets
Creators: Sunil K. Singh - Banaras Hindu University
Manoj K. Singh - University of Aveiro
Manasa K. Nayak - Banaras Hindu University
Sharda Kumari - Banaras Hindu University
Siddhartha Shrivastava - Banaras Hindu University
Jose J. A. Gracio - University of Aveiro
Debabrata Dash - Banaras Hindu University
Resource Type: Journal article
Publication Details: ACS nano, Vol.5(6), pp.4987-4996
Publisher: Amer Chemical Soc
DOI: 10.1021/nn201092p
PMID: 21574593
ISSN: 1936-0851
eISSN: 1936-086X
Number of pages: 10
Grant note: Council of Scientific and Industrial Research, New Delhi; Council of Scientific & Industrial Research (CSIR) - India Indian Council of Medical Research (ICMR) University Grants Commission, New Delhi; University Grants Commission, India Department of Biotechnology (DBT), Government of India; Department of Biotechnology (DBT) India
Language: English
Date published: 06/01/2011
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984359660902771

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