Thyroid Monitoring After Intravascular Iodinated Contrast Media in Infants and Children Through 3 Years of Age

Ryan S Miller; Jonathan R Dillman; Matthew A Crystal; Kathleen Bethin; Catherine A Dinauer; Monica Forbes-Amrein; Brent M Gordon; Bridget Hughes; Amit Lahoti; Audrey C Marshall; Lucy D Mastrandrea; Liuska M Pesce; Robert Rapaport; Arash Salavitabar; Jonathan D Wasserman; Andrew J Bauer; Ari J Wassner

doi:10.1542/peds.2026-076640

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Thyroid Monitoring After Intravascular Iodinated Contrast Media in Infants and Children Through 3 Years of Age

Journal article

Peer reviewed

Thyroid Monitoring After Intravascular Iodinated Contrast Media in Infants and Children Through 3 Years of Age

Ryan S Miller, Jonathan R Dillman, Matthew A Crystal, Kathleen Bethin, Catherine A Dinauer, Monica Forbes-Amrein, Brent M Gordon, Bridget Hughes, Amit Lahoti, Audrey C Marshall, …

Pediatrics (Evanston), Vol.157(5), e2026076640

05/01/2026

DOI: 10.1542/peds.2026-076640

PMID: 42036119

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Abstract

In March 2022, the US Food and Drug Administration issued a drug safety communication (DSC) recommending monitoring of thyroid function in children up to 3 years of age who receive intravascular injection of iodinated contrast media (IV ICM) for medical imaging. In response, a group of pediatric and imaging experts convened to review the current scientific evidence on thyroid dysfunction after IV ICM and to provide recommendations on thyroid testing and management after IV ICM administration in infants and children. There are considerable gaps in knowledge related to the risk of thyroid dysfunction in young children exposed to IV ICM, and we strongly recommend that high-quality prospective studies be proposed and funded to clarify the incidence, risk modifiers, natural history, and outcomes of thyroid dysfunction after IV ICM exposure in this population.

Child, Preschool

Contrast Media - administration & dosage

Contrast Media - adverse effects

Humans

Infant

Iodine - administration & dosage

Iodine - adverse effects

Thyroid Diseases - chemically induced

Thyroid Diseases - diagnosis

Thyroid Function Tests

Thyroid Gland - drug effects

Details

Title: Subtitle: Thyroid Monitoring After Intravascular Iodinated Contrast Media in Infants and Children Through 3 Years of Age
Creators: Ryan S Miller - Sinai Hospital
Jonathan R Dillman - Cincinnati Children's Hospital Medical Center
Matthew A Crystal - Texas Health Dallas
Kathleen Bethin - University at Buffalo, State University of New York
Catherine A Dinauer - New Haven Public Schools
Monica Forbes-Amrein - Indiana University School of Medicine
Brent M Gordon - Rady Children's Hospital-San Diego
Bridget Hughes - University at Buffalo, State University of New York
Amit Lahoti - Nationwide Children's Hospital
Audrey C Marshall - Hospital for Sick Children
Lucy D Mastrandrea - University at Buffalo, State University of New York
Liuska M Pesce - University of Iowa
Robert Rapaport - Icahn School of Medicine at Mount Sinai
Arash Salavitabar - Nationwide Children's Hospital
Jonathan D Wasserman - University of Pennsylvania
Andrew J Bauer - University of Pennsylvania
Ari J Wassner - Boston Medical Center
Resource Type: Journal article
Publication Details: Pediatrics (Evanston), Vol.157(5), e2026076640
DOI: 10.1542/peds.2026-076640
PMID: 42036119
ISSN: 1098-4275
eISSN: 1098-4275
Publisher: American Acacemy of Pediatrics
Language: English
Date published: 05/01/2026
Academic Unit: Endocrinology and Diabetes; Stead Family Department of Pediatrics
Record Identifier: 9985157605802771

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