Journal article
Thyroid hormone controls multiple independent programs required for limb development in Xenopus laevis metamorphosis
Proceedings of the National Academy of Sciences - PNAS, Vol.102(35), pp.12455-12458
08/29/2005
DOI: 10.1073/pnas.0505989102
PMCID: PMC1194953
PMID: 16129821
Abstract
Thyroid hormone (TH) is required for limb development in
Xenopus laevis
. Specific cell types in the growing limb were targeted for expression of a dominant negative form of the TH receptor by sperm-mediated transgenesis. Limb muscle development, the innervation of muscle from the spinal cord, and cartilage growth can be inhibited without affecting patterning of the limb or differentiation of other cell types. Remodeling of the skin occurs late in metamorphosis after the limb has formed. The coordination of these independent programs is affected in part by the control that TH exerts over DNA replication in all cell types of the limb.
Details
- Title: Subtitle
- Thyroid hormone controls multiple independent programs required for limb development in Xenopus laevis metamorphosis
- Creators
- Donald D. BrownLiquan Cai - Carnegie Institution for ScienceBiswajit Das - Carnegie Institution for ScienceNicholas Marsh-Armstrong - Kennedy Krieger InstituteAlexander M. Schreiber - Carnegie Institution for ScienceRejeanne Juste - Carnegie Institution for Science
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.102(35), pp.12455-12458
- DOI
- 10.1073/pnas.0505989102
- PMID
- 16129821
- PMCID
- PMC1194953
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences
- Language
- English
- Date published
- 08/29/2005
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984361722002771
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