Journal article
Tigecycline : a critical safety review
Expert opinion on drug safety, Vol.14(2), pp.335-342
02/2015
DOI: 10.1517/14740338.2015.997206
PMID: 25539800
Abstract
The emergence of multidrug-resistant (MDR) infections has been extensively observed worldwide and has become a priority issue over past decade. Tigecycline , a broad spectrum antibiotic covering against many MDR organisms, has been widely used. However, recent meta-analysis studies have raised a concern for its efficacy and safety. Reviewing tigecycline safety data would enhance the appropriate use of this medication.
This article reviews the safety profile of tigecycline, including its side effects and drug interactions.
The increased mortality associated with tigecycline is not yet well understood. Based on current evidence, alternative options must be prioritized over tigecycline if available. When tigecycline use is warranted, vigilant observation to identify any breakthrough infections and careful monitoring of progression of the original infection are highly recommended. Considering a second agent (either for synergism or enhancing coverage) may be required.
Details
- Title: Subtitle
- Tigecycline : a critical safety review
- Creators
- Quanhathai Kaewpoowat - The University of Texas Health Science Center at HoustonLuis Ostrosky-Zeichner - Weatherford College
- Resource Type
- Journal article
- Publication Details
- Expert opinion on drug safety, Vol.14(2), pp.335-342
- DOI
- 10.1517/14740338.2015.997206
- PMID
- 25539800
- ISSN
- 1474-0338
- eISSN
- 1744-764X
- Language
- English
- Date published
- 02/2015
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359852902771
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