Journal article
Tim-1 Regulates Th2 Responses in an Airway Hypersensitivity Model
European journal of immunology, Vol.42(3), pp.651-661
03/2012
DOI: 10.1002/eji.201141581
PMCID: PMC3528103
PMID: 22144095
Abstract
T cell immunoglobulin mucin-1 (Tim-1) is a transmembrane protein postulated to be a key regulator of Th2-type immune responses. This hypothesis is based in part upon genetic studies associating Tim-1 polymorphisms in mice with a bias toward airway hyperresponsiveness and the development of Th2-type CD4+ T cells. Tim-1 is expressed by Th2 CD4+ T cells on which it has been proposed to function as a co-stimulatory molecule. Tim-1 is also expressed by B cells, macrophages, and dendritic cells, but its role in responses by these cell types has not been firmly established. We generated Tim-1 deficient mice to determine the role of Tim-1 in a murine model of allergic airway disease that depends on the development and function of Th2 effector cells and results in the generation of AHR. We found antigen-driven recruitment of inflammatory cells into airways is increased in Tim-1 deficient mice relative to wild-type mice. In addition, we observed increased antigen-specific cytokine production by splenocytes from antigen-sensitized Tim-1 deficient mice relative to those from controls. These data support the conclusion that Tim-1 functions in pathways that suppress recruitment of inflammatory cells into the airways and the generation or activity of CD4+ T cells.
Details
- Title: Subtitle
- Tim-1 Regulates Th2 Responses in an Airway Hypersensitivity Model
- Creators
- Miranda Curtiss - University of Iowa Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAJacob V Gorman - Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAThomas R Businga - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAGeri Traver - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAMelody Singh - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USADavid K Meyerholz - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAJoel N Kline - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAJohn D Colgan - Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAPaul B Rothman - Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USASuzanne L Cassel - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- European journal of immunology, Vol.42(3), pp.651-661
- DOI
- 10.1002/eji.201141581
- PMID
- 22144095
- PMCID
- PMC3528103
- ISSN
- 0014-2980
- eISSN
- 1521-4141
- Grant note
- R01 AI054821 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Language
- English
- Date published
- 03/2012
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Anatomy and Cell Biology; Pathology; Immunology; Internal Medicine
- Record Identifier
- 9984025322702771
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