Journal article
Time-of-day influences on respiratory sequelae following maximal electroshock-induced seizures in mice
Journal of neurophysiology, Vol.118(5), pp.2592-2600
11/01/2017
DOI: 10.1152/jn.00039.2017
PMCID: PMC5668461
PMID: 28794189
Abstract
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in refractory epilepsy patients. Although specific mechanisms underlying SUDEP are not well understood, evidence suggests most SUDEP occurs due to seizure-induced respiratory arrest. SUDEP also tends to happen at night. Although this may be due to circumstances in which humans find themselves at night, such as being alone without supervision or sleeping prone, or to independent influences of sleep state, there are a number of reasons why the night (i.e., circadian influences) could be an independent risk factor for SUDEP. We explored this possibility. Adult male WT mice were instrumented for EEG, EMG, and EKG recording and subjected to maximal electroshock (MES) seizures during wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep during the nighttime/dark phase. These data were compared with data collected following seizures induced during the daytime/light phase. Seizures induced during the nighttime were similar in severity and duration to those induced during the daytime; however, seizures induced during the nighttime were associated with a lesser degree of respiratory dysregulation and postictal EEG suppression. Seizures induced during REM sleep during the nighttime were universally fatal, as is seen when seizures are induced during REM during the daytime. Taken together, these data implicate a role for time of day in influencing the physiological consequences of seizures that may contribute to seizure-induced death.
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. SUDEP frequently occurs during the night, which has been attributed to an effect of sleep. We have shown that sleep state does indeed influence survival following a seizure. That SUDEP occurs during the night could also implicate a circadian influence. In this study we found that time of day independently affects the physiological consequences of seizures.
Details
- Title: Subtitle
- Time-of-day influences on respiratory sequelae following maximal electroshock-induced seizures in mice
- Creators
- Benton S Purnell - Interdisciplinary Graduate Program in Neuroscience, University of Iowa Carver College of Medicine, Iowa City, IowaMichael A Hajek - Department of Neurology, Yale School of Medicine, New Haven, ConnecticutGordon F Buchanan - Department of Neurology, Yale School of Medicine, New Haven, Connecticut
- Resource Type
- Journal article
- Publication Details
- Journal of neurophysiology, Vol.118(5), pp.2592-2600
- Publisher
- United States
- DOI
- 10.1152/jn.00039.2017
- PMID
- 28794189
- PMCID
- PMC5668461
- ISSN
- 0022-3077
- eISSN
- 1522-1598
- Grant note
- R01 NS095842 / NINDS NIH HHS K08 NS069667 / NINDS NIH HHS
- Language
- English
- Date published
- 11/01/2017
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984070766202771
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