Journal article
Time to clearance of human papillomavirus infection by type and human immunodeficiency virus serostatus
International journal of cancer, Vol.119(7), pp.1623-1629
10/01/2006
DOI: 10.1002/ijc.22015
PMID: 16646070
Abstract
Persistent infection with high-risk human papillomavirus (HPV) is central to cervical carcinogenesis. Certain high-risk types, such as HPV16, may be more persistent than other HPV types, and type-specific HPV persistence may differ by HIV serostatus. This study evaluated the association between HPV type and clearance of HPV infections in 522 HIV-seropositive and 279 HIV-seronegative participants in the HIV Epidemiology Research Study (HERS, United States, 1993–2000). Type-specific HPV infections were detected using MY09/MY11/HMB01-based PCR and 26 HPV type-specific probes. The estimated duration of type-specific infections was measured from the first HPV-positive visit to the first of two consecutive negative visits. Hazard ratios (HRs) and 95% confidence intervals (CIs) for HPV clearance were calculated using Cox models adjusted for study site and risk behavior (sexual or injection drugs). A total of 1,800 HPV infections were detected in 801 women with 4.4 years median follow-up. HRs for clearance of HPV16 and related types versus low-risk HPV types were 0.79 (95% CI: 0.64–0.97) in HIV-positive women and 0.86 (95% CI: 0.59–1.27) in HIV-negative women. HRs for HPV18 versus low-risk types were 0.80 (95% CI: 0.56–1.16) and 0.57 (95% CI: 0.22–1.45) for HIV-positive and -negative women, respectively. HPV types within the high-risk category had low estimated clearance rates relative to low-risk types, but HRs were not substantially modified by HIV serostatus.
Details
- Title: Subtitle
- Time to clearance of human papillomavirus infection by type and human immunodeficiency virus serostatus
- Creators
- Jill E Koshiol - University of North Carolina at Chapel HillJane C Schroeder - University of North Carolina at Chapel HillDavid Celentano - Johns Hopkins UniversityJennifer S Smith - University of North Carolina at Chapel HillDenise J Jamieson - Centers for Disease Control and PreventionStephen W Marshall - University of North Carolina at Chapel HillAnn Duerr - Fred Hutch Cancer CenterCharles M Heilig - Centers for Disease Control and PreventionKeerti V Shah - Johns Hopkins UniversityRobert S Klein - Albert Einstein College of MedicineSusan CU-UVIN - Brown UniversityPaula Schuman - Virginia Commonwealth University
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.119(7), pp.1623-1629
- Publisher
- Wiley-Liss
- DOI
- 10.1002/ijc.22015
- PMID
- 16646070
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Language
- English
- Date published
- 10/01/2006
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446060602771
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