Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

Heidi M Harmon; Erik A Jensen; Sylvia Tan; Aasma S Chaudhary; Jonathan L Slaughter; Edward F Bell; Myra H Wyckoff; Angelita M Hensman; Gregory M Sokol; Sara B DeMauro; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

doi:10.1038/s41372-020-0594-4

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Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

Journal article

Open access

Peer reviewed

Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

Heidi M Harmon, Erik A Jensen, Sylvia Tan, Aasma S Chaudhary, Jonathan L Slaughter, Edward F Bell, Myra H Wyckoff, Angelita M Hensman, Gregory M Sokol, Sara B DeMauro, …

Journal of perinatology, Vol.40(4), pp.616-627

04/2020

DOI: 10.1038/s41372-020-0594-4

PMCID: PMC7101070

PMID: 32020038

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https://www.ncbi.nlm.nih.gov/pmc/articles/7101070View

Open Access

Abstract

To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks' postmenstrual age was used to produce adjusted odds ratios (aOR). Compared with infants in the reference group (22-28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50-63 (aOR 1.77, 95% CI 1.03-3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44-6.48). The aOR for NDI did not vary significantly by age of PNS exposure. For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.

Age Factors

Bronchopulmonary Dysplasia - classification

Bronchopulmonary Dysplasia - drug therapy

Bronchopulmonary Dysplasia - prevention & control

Cohort Studies

Dexamethasone - administration & dosage

Dexamethasone - adverse effects

Drug Administration Schedule

Female

Glucocorticoids - administration & dosage

Glucocorticoids - adverse effects

Humans

Infant

Infant Death

Infant, Extremely Premature

Infant, Newborn

Logistic Models

Male

Neurodevelopmental Disorders - chemically induced

Odds Ratio

Patient Acuity

Perinatal Death

Respiratory Distress Syndrome, Newborn - drug therapy

Retrospective Studies

Details

Title: Subtitle: Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes
Creators: Heidi M Harmon - University of Iowa
Erik A Jensen - Children's Hospital of Philadelphia
Sylvia Tan - RTI International
Aasma S Chaudhary - Children's Hospital of Philadelphia
Jonathan L Slaughter - Nationwide Children's Hospital
Edward F Bell - University of Iowa
Myra H Wyckoff - The University of Texas Southwestern Medical Center
Angelita M Hensman - Women & Infants Hospital of Rhode Island
Gregory M Sokol - Indiana University
Sara B DeMauro - Children's Hospital of Philadelphia
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Contributors: Tarah T Colaizy (Contributor) - University of Iowa, Neonatology
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.40(4), pp.616-627
DOI: 10.1038/s41372-020-0594-4
PMID: 32020038
PMCID: PMC7101070
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Grant note: UG1 HD068244 / NICHD NIH HHS UL1 TR000142 / NCATS NIH HHS U10 HD053124 / NICHD NIH HHS UG1 HD053089 / NICHD NIH HHS UG1 HD027851 / NICHD NIH HHS UG1 HD040492 / NICHD NIH HHS UG1 HD027904 / NICHD NIH HHS U24 HD095254 / NICHD NIH HHS UG1 HD068284 / NICHD NIH HHS U10 HD053119 / NICHD NIH HHS U10 HD027871 / NICHD NIH HHS UL1 RR025764 / NCRR NIH HHS UG1 HD027880 / NICHD NIH HHS U10 HD040498 / NICHD NIH HHS UG1 HD053109 / NICHD NIH HHS U10 HD021397 / NICHD NIH HHS U10 HD036790 / NICHD NIH HHS UL1 TR003167 / NCATS NIH HHS U10 HD040521 / NICHD NIH HHS UG1 HD068263 / NICHD NIH HHS UG1 HD021385 / NICHD NIH HHS KL2 TR003168 / NCATS NIH HHS UG1 HD068270 / NICHD NIH HHS UG1 HD087229 / NICHD NIH HHS UL1 TR000042 / NCATS NIH HHS UG1 HD040689 / NICHD NIH HHS UL1 TR001117 / NCATS NIH HHS UG1 HD034216 / NICHD NIH HHS U10 HD040461 / NICHD NIH HHS UG1 HD027856 / NICHD NIH HHS UL1 TR002553 / NCATS NIH HHS UG1 HD021364 / NICHD NIH HHS UG1 HD027853 / NICHD NIH HHS UG1 HD068278 / NICHD NIH HHS
Language: English
Date published: 04/2020
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984353943702771

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