Journal article
Tissue Characterization of Chronic Myocardial Infarction
Investigative radiology, Vol.25(10), pp.1120-1124
10/1990
DOI: 10.1097/00004424-199010000-00010
PMID: 2079412
Abstract
Determination of magnetic resonance (MR) relaxation times (T1 and T2) and ultrasound backscatter are potential methods of noninvasive myocardial tissue characterization. The authors postulated that infarct-related collagen deposition in a canine chronic myocardial infarction model would alter T1 and T2 relaxation times. Further, we sought to compare the changes in T1 and T2 with backscatter measurements. Eight animals were studied 4 to 6 weeks after occlusion of the left anterior descending coronary artery; standard echocardiography showed each to have left ventricular wall motion abnormalities. Time-averaged backscatter and cyclic backscatter variation (at 5 MHz) were measured in the open-chest animal with corresponding normal and infarcted areas undergoing in vitro T1 and T2 measurements (at 20 MHz) and water and hydroxyproline concentration analysis. Significant increases in T2, time-averaged ultrasound backscatter, and hydroxyproline concentration were found in the infarcted myocardium compared with normal muscle. Cyclic variation in backscatter and water content were not significantly different between the two groups. Although backscatter, T2, and tissue collagen content increased in the infarcted myocardium, a significant relationship was not found among these variables.
Details
- Title: Subtitle
- Tissue Characterization of Chronic Myocardial Infarction
- Creators
- THOMAS SCHOLZ - From the Cardiovascular Center and Departments of Pediatrics, Internal Medicine, Electrical and Computer Engineering, and Radiology, The University of Iowa, Iowa City, IowaBYRON VANDENBERGSTEVEN FLEAGLESTEVE COLLINSRICHARD KERBERDAVID SKORTON
- Resource Type
- Journal article
- Publication Details
- Investigative radiology, Vol.25(10), pp.1120-1124
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00004424-199010000-00010
- PMID
- 2079412
- ISSN
- 0020-9996
- eISSN
- 1536-0210
- Language
- English
- Date published
- 10/1990
- Academic Unit
- Radiology; Electrical and Computer Engineering; Cardiology; Stead Family Department of Pediatrics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Child and Community Health; Internal Medicine
- Record Identifier
- 9984093233702771
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