Journal article
Tissue Determinants of Nuclear Magnetic Resonance Relaxation Times: Effect of Water and Collagen Content in Muscle and Tendon
Investigative radiology, Vol.24(11), pp.893-898
11/1989
DOI: 10.1097/00004424-198911000-00010
PMID: 2807805
Abstract
Previous studies have suggested a possible relationship between tissue collagen content and nuclear magnetic resonance (NMR) relaxation times. To further investigate this relationship, we studied skeletal muscle, tendon, and the muscle/tendon transition area of normal gastrocnemius muscle from 10 dogs, and determined tissue water and collagen (hydroxyproline) content and NMR T1and T2 relaxation times at 20 MHz. Water and hydroxyproline contents and T1 and T2 were significantly different among the three tissues. Both spin-lattice and spin-spin relaxation times were linearly related to tissue water content. A significant curvilinear inverse relationship between T1 and hydroxyproline (r=0.93) and a significant inverse curvilinear relationship between T2 and hydroxyproline (r=0.92) were found. Statistically controlling for hydroxyproline concentration eliminated differences in T1 and T2 among the muscle, muscle/tendon transition, and tendon groups. Thus, NMR relaxation times of skeletal muscle and tendon appear to be influenced by both tissue water and collagen content.
Details
- Title: Subtitle
- Tissue Determinants of Nuclear Magnetic Resonance Relaxation Times: Effect of Water and Collagen Content in Muscle and Tendon
- Creators
- THOMAS SCHOLZ - From the Cardiovascular Center and, The University of Iowa, Iowa City †From the Departments of Pediatrics, The University of Iowa, Iowa City ‡From Internal Medicine, The University of Iowa, Iowa City §From Electrical and Computer Engineering, and The University of Iowa, Iowa City ∥From Preventive Medicine and Environmental Health, The University of Iowa, Iowa CitySTEVEN FLEAGLETRUDY BURNSDAVID SKORTON
- Resource Type
- Journal article
- Publication Details
- Investigative radiology, Vol.24(11), pp.893-898
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00004424-198911000-00010
- PMID
- 2807805
- ISSN
- 0020-9996
- eISSN
- 1536-0210
- Language
- English
- Date published
- 11/1989
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Child and Community Health
- Record Identifier
- 9984093343502771
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