Journal article
Tissue Engineering for the Temporomandibular Joint
Advanced healthcare materials, Vol.8(2), pp.e1801236-n/a
01/2019
DOI: 10.1002/adhm.201801236
PMCID: PMC7075314
PMID: 30556348
Abstract
Tissue engineering potentially offers new treatments for disorders of the temporomandibular joint which frequently afflict patients. Damage or disease in this area adversely affects masticatory function and speaking, reducing patients' quality of life. Effective treatment options for patients suffering from severe temporomandibular joint disorders are in high demand because surgical options are restricted to removal of damaged tissue or complete replacement of the joint with prosthetics. Tissue engineering approaches for the temporomandibular joint are a promising alternative to the limited clinical treatment options. However, tissue engineering is still a developing field and only in its formative years for the temporomandibular joint. This review outlines the anatomical and physiological characteristics of the temporomandibular joint, clinical management of temporomandibular joint disorder, and current perspectives in the tissue engineering approach for the temporomandibular joint disorder. The tissue engineering perspectives have been categorized according to the primary structures of the temporomandibular joint: the disc, the mandibular condyle, and the glenoid fossa. In each section, contemporary approaches in cellularization, growth factor selection, and scaffold fabrication strategies are reviewed in detail along with their achievements and challenges.
Details
- Title: Subtitle
- Tissue Engineering for the Temporomandibular Joint
- Creators
- Timothy M Acri - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USAKyungsup Shin - Department of Orthodontics, College of Dentistry and Dental Clinics, University of Iowa, Iowa City, Iowa, 52242, USADongrim Seol - Department of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, USANoah Z Laird - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USAIno Song - Department of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, USASean M Geary - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USAJaidev L Chakka - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USAJames A Martin - Department of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, USAAliasger K Salem - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USA
- Resource Type
- Journal article
- Publication Details
- Advanced healthcare materials, Vol.8(2), pp.e1801236-n/a
- DOI
- 10.1002/adhm.201801236
- PMID
- 30556348
- PMCID
- PMC7075314
- NLM abbreviation
- Adv Healthc Mater
- ISSN
- 2192-2640
- eISSN
- 2192-2659
- Publisher
- Germany
- Grant note
- P30 ES005605 / NIEHS NIH HHS American Association of Orthodontists Foundation 1R21DE024206-01A1 / NIH HHS P30 CA086862 / NCI NIH HHS Lyle and Sharon Bighley Professorship R21 DE024206 / NIDCR NIH HHS
- Language
- English
- Date published
- 01/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthodontics; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
- Record Identifier
- 9983985840902771
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