Journal article
Tissues from population-based cancer registries: a novel approach to increasing research potential
Human pathology, Vol.36(7), pp.812-820
2005
DOI: 10.1016/j.humpath.2005.03.010
PMID: 16084952
Abstract
Population-based cancer registries, such as those included in the Surveillance, Epidemiology, and End-Results (SEER) Program, offer tremendous research potential beyond traditional surveillance activities. We describe the expansion of SEER registries to gather formalin-fixed, paraffin-embedded tissue from cancer patients on a population basis. Population-based tissue banks have the advantage of providing an unbiased sampling frame for evaluating the public health impact of genes or protein targets that may be used for therapeutic or diagnostic purposes in defined communities. Such repositories provide a unique resource for testing new molecular classification schemes for cancer, validating new biologic markers of malignancy, prognosis and progression, assessing therapeutic targets, and measuring allele frequencies of cancer-associated genetic polymorphisms or germline mutations in representative samples. The assembly of tissue microarrays will allow for the use of rapid, large-scale protein-expression profiling of tumor samples while limiting depletion of this valuable resource. Access to biologic specimens through SEER registries will provide researchers with demographic, clinical, and risk factor information on cancer patients with assured data quality and completeness. Clinical outcome data, such as disease-free survival, can be correlated with previously validated prognostic markers. Furthermore, the anonymity of the study subject can be protected through rigorous standards of confidentiality. SEER-based tissue resources represent a step forward in true, population-based tissue repositories of tumors from US patients and may serve as a foundation for molecular epidemiology studies of cancer in this country.
Details
- Title: Subtitle
- Tissues from population-based cancer registries: a novel approach to increasing research potential
- Creators
- Marc T Goodman - Etiology Program, Hawaii Tumor Registry, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USABrenda Y Hernandez - Etiology Program, Hawaii Tumor Registry, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USAStephen Hewitt - Tissue Array Research Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USACharles F Lynch - State Health Registry of Iowa, College of Public Health, University of Iowa, Iowa City, IA 52242, USATimothy R Coté - Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USAHenry F Frierson - Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908, USAChristopher A Moskaluk - Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908, USAJeffrey L Killeen - Department of Pathology, Kapi'olani Medical Center for Women and Children, Honolulu, HI 96826, USAWendy Cozen - Los Angeles Cancer Surveillance System, University of Southern California, Los Angeles, CA 90033, USACharles R Key - New Mexico Tumor Registry, University of New Mexico Cancer Research and Treatment Center, Albuquerque, NM 87131, USALimin Clegg - Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USAMarsha Reichman - Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USABenjamin F Hankey - Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USABrenda Edwards - Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA
- Resource Type
- Journal article
- Publication Details
- Human pathology, Vol.36(7), pp.812-820
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.humpath.2005.03.010
- PMID
- 16084952
- ISSN
- 0046-8177
- eISSN
- 1532-8392
- Language
- English
- Date published
- 2005
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995033702771
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