Journal article
Titanium-Mediated Spirocyclization Reactions of 4-Alkylpyridines
Organic letters, Vol.12(15), pp.3434-3437
08/06/2010
DOI: 10.1021/ol1012636
PMID: 20670009
Abstract
Pyridines substituted at the 4-position with alkyl tethers containing β-dicarbonyl moieties were converted to spirocyclic 4,4-disubstituted dihydropyridines. Optimal conditions for these transformations involved N-acylation of the pyridine substrate with a chloroformate electrophile in the presence of Ti(OiPr)4. Cyclization products could be easily converted into spiro-piperidine derivatives or elaborated into more complex heterocyclic frameworks via Au-catalyzed cycloisomerization.
Details
- Title: Subtitle
- Titanium-Mediated Spirocyclization Reactions of 4-Alkylpyridines
- Creators
- Sharavathi G ParameswarappaF. Christopher Pigge
- Resource Type
- Journal article
- Publication Details
- Organic letters, Vol.12(15), pp.3434-3437
- Publisher
- American Chemical Society
- DOI
- 10.1021/ol1012636
- PMID
- 20670009
- ISSN
- 1523-7060
- eISSN
- 1523-7052
- Language
- English
- Date published
- 08/06/2010
- Academic Unit
- Radiology; Chemistry
- Record Identifier
- 9983985835302771
Metrics
17 Record Views