Journal article
Tobacco Xenobiotics Release Nitric Oxide
Tobacco induced diseases, Vol.1(3), pp.207-211
09/15/2003
DOI: 10.1186/1617-9625-1-3-207
PMID: 19570261
Abstract
Many xenobiotic compounds exert their actions through the release of free radicals and related oxidants [
1
,
2
], bringing about unwanted biological effects [
3
]. Indeed, oxidative events may play a significant role in tobacco toxicity from cigarette smoke. Here, we demonstrate the direct in vitro release of the free radical nitric oxide (
•
NO) from extracts and components of smokeless tobacco, including nicotine, nitrosonornicotine (NNN) and 4-(methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in phosphate buffered saline and human saliva using electron spin resonance and chemiluminescence detection. Our findings suggest that tobacco xenobiotics represent as yet unrecognized sources of
•
NO in the body.
Details
- Title: Subtitle
- Tobacco Xenobiotics Release Nitric Oxide
- Creators
- EWN Lam - Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, CanadaE E Kelley - Free Radical & Radiation Biology Graduate Program and Electron Spin Resonance Facility, The University of Iowa College of Medicine, Iowa City, Iowa, USAS M Martin - Free Radical & Radiation Biology Graduate Program and Electron Spin Resonance Facility, The University of Iowa College of Medicine, Iowa City, Iowa, USAG R Buettner - Free Radical & Radiation Biology Graduate Program and Electron Spin Resonance Facility, The University of Iowa College of Medicine, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Tobacco induced diseases, Vol.1(3), pp.207-211
- DOI
- 10.1186/1617-9625-1-3-207
- PMID
- 19570261
- NLM abbreviation
- Tob Induc Dis
- ISSN
- 2070-7266
- eISSN
- 1617-9625
- Publisher
- BioMed Central
- Language
- English
- Date published
- 09/15/2003
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984046829402771
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