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Tolerance for quinine under cholinergic versus deprivation induced thirst
Journal article   Peer reviewed

Tolerance for quinine under cholinergic versus deprivation induced thirst

Alan Kim Johnson and Alan E Fisher
Physiology & behavior, Vol.10(3), pp.613-616
1973
DOI: 10.1016/0031-9384(73)90230-8
PMID: 4708524

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Abstract

The acceptance of quinine solutions following cholinergic stimulation and following water deprivation (animals matched for water intake in separate tests) was examined in a single bottle, 1 hr exposure situation and in a tolerance test in which animals were exposed to a progression of increasing quinine concentrations. The results indicated that animals exposed to quinine 10 min after cholinergic stimulation accept significantly lower concentrations of quinine than deprived animals. However, this difference was not significant when 25 min elapsed between cholinergic stimulation and exposure to quinine. Thirst (drive strength) induced by cholinergic stimulation apparently increases for a period of time after the initial stimulation and the behavior of the animal shows convergence with that of deprived animals as time progresses. The present experiments indicate that there is no basic or qualitative difference between the states of thirst produced by cholinergic brain stimulation and by water deprivation.
Cholinergically induced drinking Deprivation drinking Quinine tolerance

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