Toll-like receptors and hypertension

Madhu V Singh; François M Abboud

doi:10.1152/ajpregu.00194.2014

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Journal article

Open access

Peer reviewed

Toll-like receptors and hypertension

Madhu V Singh and François M Abboud

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.307(5), pp.R501-R504

09/01/2014

DOI: 10.1152/ajpregu.00194.2014

PMCID: PMC4214832

PMID: 24920728

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Abstract

Hypertension and associated inflammatory processes that accelerate cardiovascular damage are regulated by the innate immune system. Toll-like receptors (TLR) are major components of the innate immune system that recognize endogenous damage-associated molecular patterns to activate prominent inflammatory signaling including activation of nuclear factor-κB (NF-κB). However, the role of TLR in the etiology of hypertension is not well understood. TLR signaling is dependent on adaptor proteins that, along with the TLR expression patterns, confer specificity of the inflammatory response and its pathological targets. Here we review the conceptual framework of how TLR and their adaptor proteins may differentially affect hypertension and cardiac hypertrophy by different stimuli.

Animals

Immunity, Innate - physiology

Humans

NF-kappa B - physiology

Cardiomegaly - physiopathology

Toll-Like Receptors - physiology

Signal Transduction - physiology

Hypertension - physiopathology

Details

Title: Subtitle: Toll-like receptors and hypertension
Creators: Madhu V Singh - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa; and madhu-singh@uiowa.edu
François M Abboud - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa; and Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.307(5), pp.R501-R504
DOI: 10.1152/ajpregu.00194.2014
PMID: 24920728
PMCID: PMC4214832
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Publisher: American Physiological Society; United States
Grant note: P01 HL014388 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS
Language: English
Date published: 09/01/2014
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984025362902771

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