Journal article
Tolterodine is equally effective in patients with mixed incontinence and those with urge incontinence alone
BJU international, Vol.92(4), pp.418-421
09/2003
DOI: 10.1046/j.1464-410X.2003.04363.x
PMID: 12930432
Abstract
OBJECTIVE: To examine the efficacy of tolterodine, an antimuscarinic agent with a bladder-selective profile, in patients with mixed incontinence (MI, stress and urge) compared with patients with urge incontinence (UI) alone. PATIENTS AND METHODS: The study included 239 patients with MI (urge predominating) and 755 with urge incontinence alone from a single-blind, multicentre trial of 1380 patients (80% female) with an overactive bladder. Those completing the trial were analysed 'per-protocol'. After a 7-day washout and a 3-day run-in to collect baseline information, patients were treated with tolterodine twice daily for 16 weeks. The two groups were compared for incontinence episodes/24 h, voiding frequency, nocturia episodes and pad usage after 16 weeks of treatment. RESULTS: After 16 weeks the median changes from baseline for all voiding variables were statistically significant for the MI and the UI groups (P < 0.001), with no apparent significant between-group differences. The median percentage reduction in incontinence episodes from baseline was 67% for the MI and 75% for the UI groups (P= 0.39). 'Dry' rates for the MI and UI groups at the end of the study were 390/0 (66/171) and 44% (243/552), respectively, whilst 24% of patients in each group (MI 40/170; UI 130/551) achieved a voiding pattern of [removed]
Details
- Title: Subtitle
- Tolterodine is equally effective in patients with mixed incontinence and those with urge incontinence alone
- Creators
- K. J Kreder - University of IowaL Brubaker - Loyola University Medical CenterT Mainprize - Foothills Medical Centre
- Resource Type
- Journal article
- Publication Details
- BJU international, Vol.92(4), pp.418-421
- Publisher
- Blackwell
- DOI
- 10.1046/j.1464-410X.2003.04363.x
- PMID
- 12930432
- ISSN
- 1464-4096
- eISSN
- 1464-410X
- Language
- English
- Date published
- 09/2003
- Academic Unit
- Obstetrics and Gynecology; Urology
- Record Identifier
- 9984383314302771
Metrics
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