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Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome
Journal article   Open access   Peer reviewed

Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome

Madalyn Walsh, Alick Feng, Petar Lenert and Bharat Kumar
Clinical Case Reports: Open Access, Vol.11(7), e7735
07/21/2023
DOI: 10.1002/ccr3.7735
PMCID: PMC10362117
PMID: 37484751
url
https://doi.org/10.1002/ccr3.7735View
Published (Version of record) Open Access

Abstract

Immune dysfunction can manifest in unexpected ways. We present the case of a patient with systemic lupus erythematosus (SLE) in whom the first sign of disseminated histoplasmosis and consequent macrophage activation syndrome (MAS) was tongue necrosis. In those with immune dysfunction, a high index of clinical suspicion for atypical infections is warranted.
histoplasmosis macrophage activation syndrome systemic lupus erythematosus tongue necrosis UIOWA OA Agreement

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