Journal article
Tonic responses of canine proximal colon: effects of eating, nutrients, and simulated diarrhea
American journal of physiology: Gastrointestinal and liver physiology, Vol.268(1), pp.G95-G101
01/01/1995
DOI: 10.1152/ajpgi.1995.268.1.G95
PMID: 7840212
Abstract
Our hypothesis was that the proximal colon relaxes to accommodate flow from the ileum. Therefore, we recorded tonic responses of the canine proximal colon to flow through the ileum and colon stimulated by 1) an 840-kcal meal, 2) nutrients perfused into the ileum and colon, or 3) rapid infusion of saline into the ileum with overflow into the colon. Saline infusion was considered to be a model of diarrhea, and the effects of an antidiarrheal (morphine sulfate) were therefore assessed. Proximal colonic tone was measured with a barostat. Tone increased before and after the arrival of chyme in the ileocolonic region. Perfusion of nutrients into the ileum and colon also significantly increased (P < 0.05) colonic tone compared with equal volumes of saline. Rapid perfusion of the ileocolonic segment with saline increased colonic tone; this increase was significantly greater (P < 0.01) when preceded by morphine. In contrast to our hypothesis, tone of the canine proximal colon increased in response to ileal flow. The increase in colonic tone during the late response to food was at least partly attributable to stimulation by intraluminal contents.
Details
- Title: Subtitle
- Tonic responses of canine proximal colon: effects of eating, nutrients, and simulated diarrhea
- Creators
- Guido Basilisco - Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota55905Sidney F Phillips - Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota55905Joseph J Cullen - Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota55905Murali Chiravuri - Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota55905
- Resource Type
- Journal article
- Publication Details
- American journal of physiology: Gastrointestinal and liver physiology, Vol.268(1), pp.G95-G101
- DOI
- 10.1152/ajpgi.1995.268.1.G95
- PMID
- 7840212
- NLM abbreviation
- Am J Physiol Gastrointest Liver Physiol
- ISSN
- 0193-1857
- eISSN
- 1522-1547
- Language
- English
- Date published
- 01/01/1995
- Academic Unit
- Surgery; Radiation Oncology
- Record Identifier
- 9984051874202771
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