Journal article
Tooth Agenesis Patterns in Orofacial Clefting Using Tooth Agenesis Code: A Meta-Analysis
Dentistry journal, Vol.10(128), p.128
07/01/2022
DOI: 10.3390/dj10070128
PMCID: PMC9323030
PMID: 35877402
Abstract
Individuals with orofacial clefting (OFC) have a higher prevalence of tooth agenesis (TA) overall. Neither the precise etiology of TA, nor whether TA occurs in patterns that differ by gender or cleft type is yet known. This meta-analysis aims to identify the spectrum of tooth agenesis patterns in subjects with non-syndromic OFC and controls using the Tooth Agenesis Code (TAC) program. An indexed search of databases (PubMed, EMBASE, and CINAHL) along with cross-referencing and hand searches were completed from May to June 2019 and re-run in February 2022. Additionally, unpublished TAC data from 914 individuals with OFC and 932 controls were included. TAC pattern frequencies per study were analyzed using a random effects meta-analysis model. A thorough review of 45 records retrieved resulted in 4 articles meeting eligibility criteria, comprising 2182 subjects with OFC and 3171 controls. No TA (0.0.0.0) was seen in 51% of OFC cases and 97% of controls. TAC patterns 0.2.0.0, 2.0.0.0, and 2.2.0.0 indicating uni- or bi-lateral missing upper laterals, and 16.0.0.0 indicating missing upper right second premolar, were more common in subjects with OFC. Subjects with OFC have unique TA patterns and defining these patterns will help increase our understanding of the complex etiology underlying TA.
Details
- Title: Subtitle
- Tooth Agenesis Patterns in Orofacial Clefting Using Tooth Agenesis Code: A Meta-Analysis
- Creators
- Brian J. Howe - University of IowaChandler Pendleton - The Iowa Institute for Oral Health Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USAMiyuraj Harishchandra Hikkaduwa Withanage - University of IowaChristopher A. Childs - University of IowaErliang Zeng - University of IowaArjen van Wijk - ACTA (United States)Ruurd Hermus - EP (United States)Carmencita Padilla - University of the Philippines ManilaJacqueline T. Hecht - Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX 77030, USAFernando A. Poletta - ECLAMC at Center for Medical Education and Clinical Research, CEMIC-CONICET, Buenos Aires 4102, ArgentinaIêda M. Orioli - Universidade Federal do Rio de JaneiroCarmen J. Buxó-Martínez - University of Puerto Rico SystemFrederic Deleyiannis - University of Colorado HealthAlexandre R. Vieira - University of PittsburghAzeez Butali - University of IowaConsuelo Valencia-Ramirez - Clinica Noel, Calle 14 No43B 146, Poblado Barrio Manila, Medellin 050034, ColombiaClaudia Restrepo Muñeton - Clinica Noel, Calle 14 No43B 146, Poblado Barrio Manila, Medellin 050034, ColombiaGeorge L. Wehby - University of IowaSeth M. Weinberg - University of PittsburghMary L. Marazita - University of PittsburghLina M. Moreno Uribe - University of IowaXian-Jin Xie - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Dentistry journal, Vol.10(128), p.128
- DOI
- 10.3390/dj10070128
- PMID
- 35877402
- PMCID
- PMC9323030
- NLM abbreviation
- Dent J (Basel)
- eISSN
- 2304-6767
- Publisher
- MDPI AG
- Grant note
- DOI: 10.13039/100000072, name: National Institute of Dental and Craniofacial Research, award: K08 DE028012, R01 DE106148, R01 DE014667, R37-DE-08559, R01 DD000295, R00 DE024571, S21 MD001830, U54 MD007587, R00 DE022378, R01 DE02830; DOI: 10.13039/100000867, name: Robert Wood Johnson Foundation, award: 72429
- Language
- English
- Date published
- 07/01/2022
- Academic Unit
- Preventive and Community Dentistry; Oral Pathology, Radiology and Medicine; Health Management and Policy; Dental Clinic Administration; Biostatistics; Craniofacial Anomalies Research Center; Family Dentistry; Hardin Library; Roy J. Carver Department of Biomedical Engineering; Orthodontics; Stead Family Department of Pediatrics; Economics; Iowa Neuroscience Institute; Public Policy Center (Archive); Dental Research
- Record Identifier
- 9984277456002771
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