Journal article
Top-Down Control of Motor Cortex Ensembles by Dorsomedial Prefrontal Cortex
Neuron (Cambridge, Mass.), Vol.52(5), pp.921-931
2006
DOI: 10.1016/j.neuron.2006.10.021
PMCID: PMC3995137
PMID: 17145511
Abstract
Dorsomedial prefrontal cortex is critical for the temporal control of behavior. Dorsomedial prefrontal cortex might alter neuronal activity in areas such as motor cortex to inhibit temporally inappropriate responses. We tested this hypothesis by recording from neuronal ensembles in rodent dorsomedial prefrontal cortex during a delayed-response task. One-third of dorsomedial prefrontal neurons were significantly modulated during the delay period. The activity of many of these neurons was predictive of premature responding. We then reversibly inactivated dorsomedial prefrontal cortex while recording ensemble activity in motor cortex. Inactivation of dorsomedial prefrontal cortex reduced delay-related firing, but not response-related firing, in motor cortex. Finally, we made simultaneous recordings in dorsomedial prefrontal cortex and motor cortex and found strong delay-related temporal correlations between neurons in the two cortical areas. These data suggest that functional interactions between dorsomedial prefrontal cortex and motor cortex might serve as a top-down control signal that inhibits inappropriate responding.
Details
- Title: Subtitle
- Top-Down Control of Motor Cortex Ensembles by Dorsomedial Prefrontal Cortex
- Creators
- Nandakumar S Narayanan - The John B. Pierce Laboratory, New Haven, Connecticut 06519Mark Laubach - The John B. Pierce Laboratory, New Haven, Connecticut 06519
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.52(5), pp.921-931
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.neuron.2006.10.021
- PMID
- 17145511
- PMCID
- PMC3995137
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Language
- English
- Date published
- 2006
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020860602771
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