Journal article
Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer
Breast cancer research : BCR, Vol.15(5), pp.316-316
2013
DOI: 10.1186/bcr3565
PMCID: PMC4054873
PMID: 24172068
Abstract
Cancer stem cells are likely to play critical roles in metastasis, therapy resistance, and recurrence of hematological and solid malignancies. It is well known that the stem cell niche plays a key role for asymmetric division and homeostasis of normal stem cells, whereas cancer stem cells seem to use these niches. Among many pathways involved in self-renewal of cancer stem cells, nuclear factor-kappa B (NF-κB) signaling has been documented to promote their expansion in a cell-autonomous fashion. A recent study, however, suggests that paracrine NF-κB activation promotes the expansion of cancer stem cells through the activation of Notch in basal-type breast cancer cells.
Details
- Title: Subtitle
- Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer
- Creators
- Weizhou Zhang - Department of Pathology, University of Iowa/Carver College of Medicine, 100 Medical Laboratories, Iowa City, IA 52241, USASergei I Grivennikov - Fox Chase Cancer Center, Cancer Prevention and Control Program, 333 Cottman Ave., Philadelphia, PA 19111, USA
- Resource Type
- Journal article
- Publication Details
- Breast cancer research : BCR, Vol.15(5), pp.316-316
- DOI
- 10.1186/bcr3565
- PMID
- 24172068
- PMCID
- PMC4054873
- NLM abbreviation
- Breast Cancer Res
- ISSN
- 1465-5411
- eISSN
- 1465-542X
- Publisher
- BioMed Central
- Language
- English
- Date published
- 2013
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984083281702771
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