Journal article
Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis
The Laryngoscope, Vol.133(9), pp.2095-2103
09/2023
DOI: 10.1002/lary.30541
PMCID: PMC10300229
PMID: 36576070
Abstract
Viral acute rhinosinusitis (ARS) is the leading cause of work and school absence and antibiotic over-prescription. There are limited treatment options available to ameliorate the symptoms caused by viral ARS. We have previously demonstrated that topical adenosine treatment enhances mucociliary clearance in the sino-nasal tract. Here, we assessed the therapeutic potential of topical adenosine in a mouse model of viral ARS.
The effect of topical adenosine on inflammatory response and mucin gene expression was examined in a mouse model of viral ARS induced by respiratory syncytial virus (RSV) nasal-only infection. We also investigated the inflammatory effect of both endogenous and exogenous adenosine in the sino-nasal tract.
Topical adenosine significantly inhibited the expression of pro-inflammatory cytokines, goblet hyperplasia, mucin expression, and cell damage in the nose of mice with viral ARS. This treatment did not prolong virus clearance. This inhibitory effect was primarily mediated by the A
adenosine receptor (AR). Although previous studies have shown that adenosine induces a robust inflammatory response in the lungs, neither endogenous nor exogenous adenosine produced inflammation in the sino-nasal tract. Instead, exogenous adenosine inhibited the baseline expression of TNF and IL-1β in the nose. Additionally, baseline expression of ARs was lower in the nose than that in the trachea and lungs.
We demonstrated that intranasal adenosine administration effectively decreased inflammation and mucus production in a mouse model of viral ARS.
N/A Laryngoscope, 2022.
Details
- Title: Subtitle
- Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis
- Creators
- Kody A Waldstein - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, USAMaria Ganama - University of IowaSteven M Varga - University of IowaStephen Tilley - University of North Carolina at Chapel HillXiaoyang Hua - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- The Laryngoscope, Vol.133(9), pp.2095-2103
- DOI
- 10.1002/lary.30541
- PMID
- 36576070
- PMCID
- PMC10300229
- NLM abbreviation
- Laryngoscope
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- Grant note
- R21 AI096139-01A1 / NIH HHS R01 AI124093 / NIH HHS University of Iowa Carver Trust Pilot Grant N5KL2TR002536-04 / NIH HHS T32 AI007485 / NIH HHS
- Language
- English
- Electronic publication date
- 12/28/2022
- Date published
- 09/2023
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology; Otolaryngology
- Record Identifier
- 9984354111402771
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